The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).
功能Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.
疾病相关Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.
序列相似性Belongs to the PRP31 family. Contains 1 Nop domain.
结构域Interacts with the snRNP via the Nop domain. The coiled coil domain is formed by two non-contiguous helices.
细胞定位Nucleus speckle. Nucleus > Cajal body. Predominantly found in speckles and in Cajal bodies.