Anti-PROX1抗体(ab101851)

概述

  • 产品名称Anti-PROX1抗体
    参阅全部 PROX1 一抗
  • 描述
    兔多克隆抗体to PROX1
  • 经测试应用适用于: ICC/IF, WB, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant fragment corresponding to Human PROX1 (C terminal). (Homeo domain and Prospero domain)
    Database link: Q92786

性能

应用

Our Abpromise guarantee covers the use of ab101851 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF 1/750 - 1/1000.
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 82 kDa.
IHC-Fr Use at an assay dependent concentration.

靶标

  • 功能Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • 组织特异性Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • 序列相似性Belongs to the Prospero homeobox family.
    Contains 1 Prospero-type homeobox DNA-binding domain.
  • 结构域The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • 细胞定位Nucleus. RORG promotes its nuclear localization.
  • Information by UniProt
  • 数据库链接
  • 形式Prox1 is a specific and required regulator of the development of the lymphatic system and that the vascular and lymphatic systems develop independently. Sox18 directly activates Prox1 transcription by binding to its proximal promoter.
  • 别名
    • Homeobox prospero like protein antibody
    • Homeobox prospero like protein PROX1 antibody
    • Homeobox prospero-like protein PROX1 antibody
    • Prospero homeobox 1 antibody
    • Prospero homeobox protein 1 antibody
    • Prospero related homeobox 1 antibody
    • prospero-related homeobox gene 1 antibody
    • PROX 1 antibody
    • PROX-1 antibody
    • PROX1 antibody
    • PROX1_HUMAN antibody
    • zgc:111888 antibody
    see all

Anti-PROX1 antibody 图像

  • Immunohistochemistry (Frozen sections) analysis of mouse embryo (day 13.5) tissue sections labelling PROX1 (red) with ab101851. Green - CD31, lv - large vessel, arrows - blood vessels, sg - sympathetic ganglion.

Anti-PROX1 antibody (ab101851)参考文献

ab101851 has not yet been referenced specifically in any publications.

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (h9 cell line upon differentiation)
Specification h9 cell line upon differentiation
Blocking step Serum as blocking agent for 10 minute(s) · Concentration: 5% · Temperature: 25°C
Fixative Paraformaldehyde
Username

Abcam user community

Verified customer

提交于 Oct 22 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"