Anti-PROX1抗体[5G10] (ab92825)

概述

  • 产品名称Anti-PROX1抗体[5G10]
    参阅全部 PROX1 一抗
  • 描述
    小鼠单克隆抗体[5G10] to PROX1
  • 特异性Specific to PROX1
  • 经测试应用适用于: IHC-FoFrmore details
  • 种属反应性
    与反应: Mouse, Rat, Chicken, Human
    预测可用于: a wide range of other species
  • 免疫原

    Recombinant Human PROX1 protein.

  • 阳性对照
    • Rat denate gyrus tissue

性能

应用

Our Abpromise guarantee covers the use of ab92825 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-FoFr 1/1000.

靶标

  • 功能Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • 组织特异性Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • 序列相似性Belongs to the Prospero homeobox family.
    Contains 1 Prospero-type homeobox DNA-binding domain.
  • 结构域The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • 细胞定位Nucleus. RORG promotes its nuclear localization.
  • Information by UniProt
  • 数据库链接
  • 形式Prox1 is a specific and required regulator of the development of the lymphatic system and that the vascular and lymphatic systems develop independently. Sox18 directly activates Prox1 transcription by binding to its proximal promoter.
  • 别名
    • Homeobox prospero like protein antibody
    • Homeobox prospero like protein PROX1 antibody
    • Homeobox prospero-like protein PROX1 antibody
    • Prospero homeobox 1 antibody
    • Prospero homeobox protein 1 antibody
    • Prospero related homeobox 1 antibody
    • prospero-related homeobox gene 1 antibody
    • PROX 1 antibody
    • PROX-1 antibody
    • PROX1 antibody
    • PROX1_HUMAN antibody
    • zgc:111888 antibody
    see all

Anti-PROX1 antibody [5G10] 图像

  • ab92825, at a 1/1000 dilution in 0.1% BSA with 0.25% triton-X-100 in 0.1 M tris-saline, staining PROX1 in rat dentate gyrus tissue by immunohistochemistry (perfusion). The tissue was fixed via transcaridal perfusion with 2% paraformaldehyde and 3.75% acrolein in 0.1 M phosphate buffer (pH 7.4). Detection: DAB staining (6 minutes)

Anti-PROX1 antibody [5G10] (ab92825)参考文献

ab92825 has not yet been referenced specifically in any publications.

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 37°C
Sample Mouse Cell (mouse lens tissue)
Specification mouse lens tissue
Permeabilization Yes - 0.25%triton for 12mins
Fixative Formaldehyde
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提交于 Jul 01 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"