Anti-Prothrombin抗体[BDI095] (ab22700)

概述

  • 产品名称Anti-Prothrombin抗体[BDI095]
    参阅全部 Prothrombin 一抗
  • 描述
    小鼠单克隆抗体[BDI095] to Prothrombin
  • 特异性ab22700 binds human prothrombin, specifically fragment 2.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native protein (purified) (Human). Purified Human Prothrombin

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 0.15M Sodium chloride, 10mM Soudium dihydrogen phosphate, 1% Mannitol. pH 7.4
  • Concentration information loading...
  • 纯化说明Antibody was purified by Gel filtration and ion exchange chromatography and the purity determined by 10% SDS-PAGE.
  • 克隆单克隆
  • 克隆编号BDI095
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab22700 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: Use at a concentration of 1 - 5 µg/ml. WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 70 kDa. Dilution optimised using Chromogenic detection. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
    • 组织特异性Expressed by the liver and secreted in plasma.
    • 疾病相关Defects in F2 are the cause of factor II deficiency (FA2D) [MIM:613679]. It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.
      Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
      Defects in F2 are a cause of susceptibility to thrombosis (THR) [MIM:188050]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis.
    • 序列相似性Belongs to the peptidase S1 family.
      Contains 1 Gla (gamma-carboxy-glutamate) domain.
      Contains 2 kringle domains.
      Contains 1 peptidase S1 domain.
    • 翻译后修饰The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.
    • 细胞定位Secreted > extracellular space.
    • Information by UniProt
    • 数据库链接
    • 形式Cleaved into the following 4 chains: 1. Activation peptide fragment 1 2. Activation peptide fragment 2 3. Thrombin light chain 4. Thrombin heavy chain
    • 别名
      • coagulation factor II (thrombin) antibody
      • Coagulation factor II antibody
      • F2 antibody
      • Factor II antibody
      • Prepro coagulation factor II antibody
      • Prothrombin antibody
      • prothrombin B-chain antibody
      • PT antibody
      • RPRGL2 antibody
      • serine protease antibody
      • THPH1 antibody
      • THRB antibody
      • THRB_HUMAN antibody
      • Thrombin heavy chain antibody
      see all

    Anti-Prothrombin antibody [BDI095] (ab22700)参考文献

    ab22700 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab22700.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"