Anti-Protein S抗体(Biotin) (ab105368)

概述

  • 产品名称
    Anti-Protein S抗体(Biotin)
    参阅全部 Protein S 一抗
  • 描述
    兔多克隆抗体to Protein S (Biotin)
  • 偶联物
    Biotin
  • 经测试应用
    适用于: WB, RIA, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human Protein S purified from Human plasma.

性能

应用

Our Abpromise guarantee covers the use of ab105368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 75 kDa.
RIA Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

靶标

  • 功能
    Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
  • 组织特异性
    Plasma.
  • 疾病相关
    Defects in PROS1 are the cause of protein S deficiency (PROS1D) [MIM:612336]; also known as thrombophilia due to protein S deficiency. PROS1D is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity.
  • 序列相似性
    Contains 4 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 2 laminin G-like domains.
  • 翻译后修饰
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Preproprotein S antibody
    • Propiece of latent protein S antibody
    • PROS 1 antibody
    • PROS antibody
    • PROS_HUMAN antibody
    • proS1 antibody
    • Protein S alpha antibody
    • Protein Sa antibody
    • PS 21 antibody
    • PS 22 antibody
    • PS 23 antibody
    • PS 24 antibody
    • PS 25 antibody
    • PS 26 antibody
    • PS21 antibody
    • PS22 antibody
    • PS23 antibody
    • PS24 antibody
    • PS25 antibody
    • PS26 antibody
    • PSA antibody
    • THPH5 antibody
    • THPH6 antibody
    • Vitamin K dependent protein S antibody
    • Vitamin K-dependent plasma protein S antibody
    • Vitamin K-dependent protein S antibody
    see all

实验方案

Anti-Protein S antibody (Biotin) (ab105368)参考文献

ab105368 has not yet been referenced specifically in any publications.

Product Wall

Application
ELISA
Sample
Human Cell (human macrophages)
Specification
human macrophages
Type
Sandwich (Detection)
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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提交于 Jan 08 2014

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