概述

  • 产品名称
    Anti-Protein S抗体
    参阅全部 Protein S 一抗
  • 描述
    兔多克隆抗体to Protein S
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 650 to the C-terminus of Human Protein S.

    (Peptide available as ab90639.)

  • 阳性对照
    • This antibody gave a positive signal in human plasma total protein.

性能

应用

Our Abpromise guarantee covers the use of ab78281 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 77, 90 kDa (predicted molecular weight: 75 kDa).

靶标

  • 功能
    Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
  • 组织特异性
    Plasma.
  • 疾病相关
    Defects in PROS1 are the cause of protein S deficiency (PROS1D) [MIM:612336]; also known as thrombophilia due to protein S deficiency. PROS1D is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity.
  • 序列相似性
    Contains 4 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 2 laminin G-like domains.
  • 翻译后修饰
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Preproprotein S antibody
    • Propiece of latent protein S antibody
    • PROS 1 antibody
    • PROS antibody
    • PROS_HUMAN antibody
    • proS1 antibody
    • Protein S alpha antibody
    • Protein Sa antibody
    • PS 21 antibody
    • PS 22 antibody
    • PS 23 antibody
    • PS 24 antibody
    • PS 25 antibody
    • PS 26 antibody
    • PS21 antibody
    • PS22 antibody
    • PS23 antibody
    • PS24 antibody
    • PS25 antibody
    • PS26 antibody
    • PSA antibody
    • THPH5 antibody
    • THPH6 antibody
    • Vitamin K dependent protein S antibody
    • Vitamin K-dependent plasma protein S antibody
    • Vitamin K-dependent protein S antibody
    see all

图片

  • Anti-Protein S antibody (ab78281) at 1 µg/ml + Human Plasma Total Protein Lysate at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 75 kDa
    Observed band size : 77 + 90 kDa (why is the actual band size different from the predicted?)


    Exposure time : 20 minutes

实验方案

文献

ab78281 has not yet been referenced specifically in any publications.

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