Anti-Protein Phosphatase 1 beta抗体[AF9B12] (ab80942)

概述

  • 产品名称Anti-Protein Phosphatase 1 beta抗体[AF9B12]
    参阅全部 Protein Phosphatase 1 beta 一抗
  • 描述
    小鼠单克隆抗体[AF9B12] to Protein Phosphatase 1 beta
  • 特异性ab80942 does not cross react with PPP1C alpha and PPP1C gamma.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant human Protein Phosphatase 1 beta purified from E.coli (His-Protein Phosphatase 1 beta)

  • 阳性对照
    • Jurkat, MOLT4, HT29, A431, SKNSH, PC12 and NIH3T3 cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab80942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa).

靶标

  • 功能Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
  • 序列相似性Belongs to the PPP phosphatase family. PP-1 subfamily.
  • 细胞定位Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC3672 antibody
    • PP 1B antibody
    • PP-1B antibody
    • PP1B antibody
    • PP1B_HUMAN antibody
    • PP1beta antibody
    • PPP1CB antibody
    • PPP1CD antibody
    • Protein phosphatase 1 beta antibody
    • Protein phosphatase 1 catalytic subunit beta isoform antibody
    • Protein phosphatase 1 delta antibody
    • Protein phosphatase 1, catalytic subunit, beta isozyme antibody
    • Protein phosphatase 1, catalytic subunit, delta isoform antibody
    • Serine threonine protein phosphatase PP1 beta catalytic subunit antibody
    • Serine/threonine-protein phosphatase PP1-beta catalytic subunit antibody
    see all

Anti-Protein Phosphatase 1 beta antibody [AF9B12] 图像

  • All lanes : Anti-Protein Phosphatase 1 beta antibody [AF9B12] (ab80942)

    Lane 1 : Jurkat cell lysate
    Lane 2 : MOLT4 cell lysate
    Lane 3 : HT29 cell lysate
    Lane 4 : A431 cell lysate
    Lane 5 : SKNSH cell lysate
    Lane 6 : PC12 cell lysate
    Lane 7 : NIH3T3 cell lysate


    Predicted band size : 37 kDa
    Observed band size : 37 kDa

Anti-Protein Phosphatase 1 beta antibody [AF9B12] (ab80942)参考文献

ab80942 has not yet been referenced specifically in any publications.

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