Anti-Protein Phosphatase 1 beta抗体(ab16369)

概述

  • 产品名称Anti-Protein Phosphatase 1 beta抗体
    参阅全部 Protein Phosphatase 1 beta 一抗
  • 描述
    羊多克隆抗体to Protein Phosphatase 1 beta
  • 特异性No cross reactivity is seen with other recombinant PP1 isoforms.
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Chicken, Pig
  • 免疫原

    Synthetic peptide:

    PRTANPPKKR

    conjugated to KLH, corresponding to amino acids 318-327 of Human PPP1B.

性能

应用

Our Abpromise guarantee covers the use of ab16369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 37 kDa.
IP Use at an assay dependent dilution.

靶标

  • 功能Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
  • 序列相似性Belongs to the PPP phosphatase family. PP-1 subfamily.
  • 细胞定位Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC3672 antibody
    • PP 1B antibody
    • PP-1B antibody
    • PP1B antibody
    • PP1B_HUMAN antibody
    • PP1beta antibody
    • PPP1CB antibody
    • PPP1CD antibody
    • Protein phosphatase 1 beta antibody
    • Protein phosphatase 1 catalytic subunit beta isoform antibody
    • Protein phosphatase 1 delta antibody
    • Protein phosphatase 1, catalytic subunit, beta isozyme antibody
    • Protein phosphatase 1, catalytic subunit, delta isoform antibody
    • Serine threonine protein phosphatase PP1 beta catalytic subunit antibody
    • Serine/threonine-protein phosphatase PP1-beta catalytic subunit antibody
    see all

Anti-Protein Phosphatase 1 beta antibody (ab16369)参考文献

This product has been referenced in:
  • Miyazaki Y  et al. Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling. PLoS One 7:e35875 (2012). WB . Read more (PubMed: 22558250) »
  • Aoyama H  et al. Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca(2+) cycling. Cardiovasc Res 89:79-88 (2011). Read more (PubMed: 20675715) »

See all 2 Publications for this product

Product Wall

Thank you for your response. I would like to confirm that every batch has been tested QC analysis and have just placed a new order for you for one vial of ab16369 as a free of charge replacement. Your new order number is 136944 and as you should be...

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Thank you for your email. As the antibody is currently out of stock, it will take approximately 3-4 weeks for a new batch to come into stock. I unfortunately can't hasten the process. Please contact us again if you have any additional questions.

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Thank you for your enquiry. I checked this antibody, and the sequence of the peptide used to generate ab16369 was indeed PRTANPPKKR, corresponding to amino acids 318-327 of Human PPP1B. However, the database links were wrong and I have updated them. Th...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"