Anti-Protein C抗体(ab61363)

概述

  • 产品名称Anti-Protein C抗体
    参阅全部 Protein C 一抗
  • 描述
    小鼠单克隆抗体to Protein C
  • 特异性Recognises protein C and activated protein C
  • 经测试应用适用于: WB, ELISA, RIAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native purified Human Protein C

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 50% Glycerol, Water
  • Concentration information loading...
  • 纯度Ion Exchange Chromatography
  • 纯化说明Salt fractionation followed by gel filtration and ion exchange chromatography
  • 克隆单克隆
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab61363 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 52 kDa.
ELISA Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

靶标

  • 功能Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
  • 组织特异性Plasma; synthesized in the liver.
  • 疾病相关Thrombophilia due to protein C deficiency, autosomal dominant
    Thrombophilia due to protein C deficiency, autosomal recessive
  • 序列相似性Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • 翻译后修饰The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
    N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
  • 细胞定位Secreted. Golgi apparatus. Endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activation peptide antibody
    • Anticoagulant protein C antibody
    • APC antibody
    • Autoprothrombin IIA antibody
    • Blood coagulation factor XIV antibody
    • EC 3.4.21.69 antibody
    • PC antibody
    • proC antibody
    • PROC_HUMAN antibody
    • PROC1 antibody
    • Protein C (inactivator of coagulation factors Va and VIIIa) antibody
    • THPH3 antibody
    • THPH4 antibody
    • Vitamin K dependent protein C antibody
    see all

Anti-Protein C antibody (ab61363)参考文献

ab61363 has not yet been referenced specifically in any publications.

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All of these antibodies are raised against full length Protein C. So we do not know what epitope(s) will be recognized by these antibodies.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"