Anti-Protein C抗体(ab48623)

概述

  • 产品名称
    Anti-Protein C抗体
    参阅全部 Protein C 一抗
  • 描述
    兔多克隆抗体to Protein C
  • 经测试应用
    适用于: RIA, WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native protein purified from human plasma

性能

应用

Our Abpromise guarantee covers the use of ab48623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
RIA Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 52 kDa.
ELISA Use at an assay dependent concentration.

靶标

  • 功能
    Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
  • 组织特异性
    Plasma; synthesized in the liver.
  • 疾病相关
    Thrombophilia due to protein C deficiency, autosomal dominant
    Thrombophilia due to protein C deficiency, autosomal recessive
  • 序列相似性
    Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • 翻译后修饰
    The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
    N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
  • 细胞定位
    Secreted. Golgi apparatus. Endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activation peptide antibody
    • Anticoagulant protein C antibody
    • APC antibody
    • Autoprothrombin IIA antibody
    • Blood coagulation factor XIV antibody
    • EC 3.4.21.69 antibody
    • PC antibody
    • proC antibody
    • PROC_HUMAN antibody
    • PROC1 antibody
    • Protein C (inactivator of coagulation factors Va and VIIIa) antibody
    • THPH3 antibody
    • THPH4 antibody
    • Vitamin K dependent protein C antibody
    see all

实验方案

文献

ab48623 has not yet been referenced specifically in any publications.

客户评价及客户问答

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Thank you for your enquiry.

All of these antibodies are raised against full length Protein C. So we do not know what epitope(s) will be recognized by these antibodies.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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