Anti-Protective protein/Cathepsin A (PPCA)抗体(ab111752)

概述

  • 产品名称Anti-Protective protein/Cathepsin A (PPCA)抗体
    参阅全部 Protective protein/Cathepsin A (PPCA) 一抗
  • 描述
    兔多克隆抗体to Protective protein/Cathepsin A (PPCA)
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide within Human Protective protein/Cathepsin A (PPCA) aa 25-53 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: NP_001161066.1

  • 阳性对照
    • HepG2 cells or mouse bladder tissue lysates; Human hepatocarcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab111752 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 46 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
  • 疾病相关Defects in CTSA are the cause of galactosialidosis (GSL) [MIM:256540]. A lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival.
  • 序列相似性Belongs to the peptidase S10 family.
  • 细胞定位Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • beta galactosidase 2 antibody
    • BETA GALACTOSIDASE PROTECTIVE PROTEIN antibody
    • beta-galactosidase 2 antibody
    • beta-galactosidase protective protein antibody
    • betagalactosidase 2 antibody
    • Carboxypeptidase C antibody
    • Carboxypeptidase L antibody
    • carboxypeptidase Y-like kininase antibody
    • Cathepsin A antibody
    • Ctsa antibody
    • deamidase antibody
    • EC 3.4.16.5 antibody
    • Glactosialidosis antibody
    • GLB2 antibody
    • Goldberg Syndrome antibody
    • GSL antibody
    • lysosomal carboxypeptidase A antibody
    • Lysosomal protective protein 20 kDa chain antibody
    • Lysosomal protective protein antibody
    • Lysosomal protective protein deficiency antibody
    • NEURAMINIDASE BETA GALACTOSIDASE EXPRESSION; NGBE antibody
    • Neuraminidase deficiency with beta-galactosidase deficiency antibody
    • NGBE antibody
    • OTTHUMP00000031778 antibody
    • OTTHUMP00000031781 antibody
    • PPCA antibody
    • PPCA deficiency antibody
    • PPGB antibody
    • PPGB_HUMAN antibody
    • Protective protein cathepsin A antibody
    • Protective protein for beta galactosidase antibody
    • Protective protein for beta-galactosidase antibody
    • Protective protein/cathepsin A deficiency antibody
    • urinary kininase antibody
    see all

Anti-Protective protein/Cathepsin A (PPCA) antibody 图像

  • Immunohistochemistry analysis of Protective protein/Cathepsin A (PPCA) expression in formalin fixed and paraffin embedded Human hepatocarcinoma tissue using 1/50 ab111752 followed by a peroxidase conjugated secondary antibody and DAB staining.

  • Anti-Protective protein/Cathepsin A (PPCA) antibody (ab111752) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 46 kDa
  • Anti-Protective protein/Cathepsin A (PPCA) antibody (ab111752) at 1/100 dilution + mouse bladder tissue lysates at 35 µg

    Predicted band size : 46 kDa

Anti-Protective protein/Cathepsin A (PPCA) antibody (ab111752)参考文献

ab111752 has not yet been referenced specifically in any publications.

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In general the level of homology between the Xenopus and Human is low and when I compared the immunogen sequence of ab111752 and the other 3 PAX1 antibodies we have in our catalogue, the level of homology is re...

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