The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human proteasome 20S beta 7, catalog ab3332. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Macropain chain Z
Multicatalytic endopeptidase complex chain Z
Proteasome (prosome macropain) subunit beta type 7
Proteasome beta 7 subunit
Proteasome catalytic subunit 2
Proteasome subunit alpha
Proteasome subunit beta 7
Proteasome subunit beta type-7
Proteasome subunit Z
功能The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.
组织特异性Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues.