概述

  • 产品名称Prostratin
  • 描述
    PKC activator; reactivates HIV-1 latency
  • 生物学描述PKC activator; reactivates HIV-1 latency (IC50 = ~0.5 µM) by PKC dependent NF-κB activation. Downregulates expression of HIV-1 receptor CD4 and its co-receptors CXCR4 and CCR5 in vitro. Non-tumor promoting.
  • 纯度> 98%

性能

    Prostratin (ab120880)参考文献

    This product has been referenced in:
    • Bedoya LM  et al. SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro. Biochem Pharmacol 77:965-78 (2009). Read more (PubMed: 19100719) »
    • Wender PA  et al. Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV. Science 320:649-52 (2008). Read more (PubMed: 18451298) »
    • Kulkosky J  et al. Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood 98:3006-15 (2001). Read more (PubMed: 11698284) »

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