Prostaglandin dehydrogenase 1肽(255-266) (ab45650)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-DYDTTPFQAKTQ
    • 氨基酸255 to 266

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45650 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Prostaglandin dehydrogenase 1 antibody (ab26076)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

常规信息

  • 别名
    • 15 hydroxyprostaglandin dehydrogenase [NAD+]
    • 15 PGDH
    • 15-hydroxyprostaglandin dehydrogenase [NAD+]
    • 15-PGDH
    • 15PGDH
    • Hpgd
    • Hydroxyprostaglandin dehydrogenase 15 (NAD)
    • NAD+ dependent 15 hydroxyprostaglandin dehydrogenase
    • OTTHUMP00000218960
    • OTTHUMP00000219016
    • OTTHUMP00000219018
    • PGDH
    • PGDH_HUMAN
    • PGDH1
    • PHOAR1
    • Prostaglandin dehydrogenase 1
    • SDR36C1
    • Short chain dehydrogenase/reductase family 36C member 1
    see all
  • 功能Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
  • 组织特异性Detected in colon epithelium (at protein level).
  • 疾病相关Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) [MIM:259100]; also known as pachydermoperiostosis autosomal recessive. Primary hypertrophic osteoarthropathy is characterized by digital clubbing, osterarthropathy, variable features of pachydermia, delayed closure of the fontanels, and congenital heart disease.
    Defects in HPGD are the cause of cranioosteoarthropathy (COA) [MIM:259100]. Clinical features include infantile onset of swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature.
    Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC) [MIM:119900]; also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved.
  • 序列相似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Prostaglandin dehydrogenase 1 peptide (255-266) (ab45650)参考文献

ab45650 has not yet been referenced specifically in any publications.

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