Anti-Prostaglandin dehydrogenase 1抗体(ab26076)

概述

  • 产品名称
    Anti-Prostaglandin dehydrogenase 1抗体
    参阅全部 Prostaglandin dehydrogenase 1 一抗
  • 描述
    山羊多克隆抗体to Prostaglandin dehydrogenase 1
  • 特异性
    ab26076 recognises Prostaglandin dehydrogenase 1.
  • 经测试应用
    适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    C DYDTTPFQAKTQ

    , corresponding to C terminal amino acids 255-266 of Human Prostaglandin dehydrogenase 1

  • 阳性对照
    • Human duodenum lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: Tris saline, 0.5% BSA. pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab26076 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/128000.
WB Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 26, 50 kDa (predicted molecular weight: 30 kDa).

靶标

  • 功能
    Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
  • 组织特异性
    Detected in colon epithelium (at protein level).
  • 疾病相关
    Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) [MIM:259100]; also known as pachydermoperiostosis autosomal recessive. Primary hypertrophic osteoarthropathy is characterized by digital clubbing, osterarthropathy, variable features of pachydermia, delayed closure of the fontanels, and congenital heart disease.
    Defects in HPGD are the cause of cranioosteoarthropathy (COA) [MIM:259100]. Clinical features include infantile onset of swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature.
    Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC) [MIM:119900]; also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved.
  • 序列相似性
    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 15 hydroxyprostaglandin dehydrogenase [NAD+] antibody
    • 15 PGDH antibody
    • 15-hydroxyprostaglandin dehydrogenase [NAD+] antibody
    • 15-PGDH antibody
    • 15PGDH antibody
    • Hpgd antibody
    • Hydroxyprostaglandin dehydrogenase 15 (NAD) antibody
    • NAD+ dependent 15 hydroxyprostaglandin dehydrogenase antibody
    • OTTHUMP00000218960 antibody
    • OTTHUMP00000219016 antibody
    • OTTHUMP00000219018 antibody
    • PGDH antibody
    • PGDH_HUMAN antibody
    • PGDH1 antibody
    • PHOAR1 antibody
    • Prostaglandin dehydrogenase 1 antibody
    • SDR36C1 antibody
    • Short chain dehydrogenase/reductase family 36C member 1 antibody
    see all

图片

  • Anti-Prostaglandin dehydrogenase 1 antibody (ab26076) at 0.1 µg/ml + Human duodenal lysate (35ug) at 35 µg
    Developed using the ECL technique

    Predicted band size : 30 kDa
    Observed band size : 26 & 50 kDa (why is the actual band size different from the predicted?)

实验方案

文献

ab26076 has not yet been referenced specifically in any publications.

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