Anti-Prostaglandin dehydrogenase 1抗体(ab118185)

概述

  • 产品名称Anti-Prostaglandin dehydrogenase 1抗体
    参阅全部 Prostaglandin dehydrogenase 1 一抗
  • 描述
    小鼠单克隆抗体to Prostaglandin dehydrogenase 1
  • 经测试应用适用于: WB, IP, IHC-P, Sandwich ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-267 of Human Prostaglandin dehydrogenase 1 (AAH18986), with a proprietary tag.

  • 阳性对照
    • Recombinant Protein. Prostaglandin dehydrogenase 1 transfected 293T cell line. Human placenta tissue.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab118185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 29 kDa.
IP Use at an assay dependent concentration.
IHC-P Use a concentration of 3 µg/ml.
Sandwich ELISA Use at an assay dependent concentration.

靶标

  • 功能Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
  • 组织特异性Detected in colon epithelium (at protein level).
  • 疾病相关Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) [MIM:259100]; also known as pachydermoperiostosis autosomal recessive. Primary hypertrophic osteoarthropathy is characterized by digital clubbing, osterarthropathy, variable features of pachydermia, delayed closure of the fontanels, and congenital heart disease.
    Defects in HPGD are the cause of cranioosteoarthropathy (COA) [MIM:259100]. Clinical features include infantile onset of swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature.
    Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC) [MIM:119900]; also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved.
  • 序列相似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 15 hydroxyprostaglandin dehydrogenase [NAD+] antibody
    • 15 PGDH antibody
    • 15-hydroxyprostaglandin dehydrogenase [NAD+] antibody
    • 15-PGDH antibody
    • 15PGDH antibody
    • Hpgd antibody
    • Hydroxyprostaglandin dehydrogenase 15 (NAD) antibody
    • NAD+ dependent 15 hydroxyprostaglandin dehydrogenase antibody
    • OTTHUMP00000218960 antibody
    • OTTHUMP00000219016 antibody
    • OTTHUMP00000219018 antibody
    • PGDH antibody
    • PGDH_HUMAN antibody
    • PGDH1 antibody
    • PHOAR1 antibody
    • Prostaglandin dehydrogenase 1 antibody
    • SDR36C1 antibody
    • Short chain dehydrogenase/reductase family 36C member 1 antibody
    see all

Anti-Prostaglandin dehydrogenase 1 antibody 图像

  • All lanes : Anti-Prostaglandin dehydrogenase 1 antibody (ab118185) at 5 µg/ml

    Lane 1 : HPGD transfected 293T cell line lysate
    Lane 2 : Non transfected 293T cell line lysate

    Lysates/proteins at 25 µg per lane.

    Developed using the ECL technique

    Predicted band size : 29 kDa
  • ab118185 at 3 µg/ml staining Prostaglandin dehydrogenase 1 in Formalin-Fixed, Paraffin-Embedded Human Placenta tissue by Immunohistochemistry.
  • Immunoprecipitation of Prostaglandin dehydrogenase 1 from transfected lysate using ab118185 and Protein A Magnetic beads. Detection by WB utilised an alternative anti-Prostaglandin dehydrogenase 1 rabbit polyclonal antibody.
  • ab118185 at 10 µg/ml as a capture antibody. The detection limit for recombinant tagged Prostaglandin dehydrogenase 1 is 0.3 ng/ml.

Anti-Prostaglandin dehydrogenase 1 antibody (ab118185)参考文献

ab118185 has not yet been referenced specifically in any publications.

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