Anti-Properdin抗体[3B10] (ab25850)

概述

  • 产品名称
    Anti-Properdin抗体[3B10]
    参阅全部 Properdin 一抗
  • 描述
    小鼠单克隆抗体[3B10] to Properdin
  • 特异性
    ab25850 recognises human properdin.
  • 经测试应用
    适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Properdin isolated from human plasma.

  • 表位
    Epitope specificity differs from that of ab17780 but slightly overlap as determined by inhibition ELISA.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 15mM Sodium Azide
    Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 克隆
    单克隆
  • 克隆编号
    3B10
  • 骨髓瘤
    x63-Ag8.653
  • 同种型
    IgG1
  • 轻链类型
    kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab25850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/8000. (based on use as detection antibody for antigen coated at 0.3 µg/ml).
WB Use at an assay dependent dilution. Recognises both reduced and unreduced forms of the protein.
AP Use at an assay dependent dilution. Suitable for affinity purification of human properdin after coupling to an activated CNBr-sepharose column.

靶标

  • 功能
    A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
  • 疾病相关
    Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).
  • 序列相似性
    Contains 6 TSP type-1 domains.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BFD antibody
    • CFP antibody
    • Complement factor P antibody
    • Complement factor properdin antibody
    • Factor P antibody
    • PFC antibody
    • PFD antibody
    • PROP_HUMAN antibody
    • Properdin antibody
    • Properdin P factor complement antibody
    see all

实验方案

文献

ab25850 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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