Anti-Prokineticin 1抗体(ab42802)

概述

  • 产品名称
    Anti-Prokineticin 1抗体
    参阅全部 Prokineticin 1 一抗
  • 描述
    兔多克隆抗体to Prokineticin 1
  • 特异性
    The polyclonal antibody reacts specificly with human prokinectin 1.
  • 经测试应用
    适用于: WB, Flow Cyt, IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from N terminal region of Human prokinectin 1

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液
    Preservative: None
    Constituents: Whole serum
  • 纯度
    Whole antiserum
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab42802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/200. Predicted molecular weight: 12 kDa.Can be blocked with Prokineticin 1 peptide (ab206194).
Flow Cyt 1/100. ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
IHC-P 1/50.
IHC-Fr 1/50.

靶标

  • 功能
    Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.
  • 组织特异性
    Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.
  • 序列相似性
    Belongs to the AVIT (prokineticin) family.
  • 发展阶段
    In adult testis, is strongly expressed only in Leydig cells. In testicular tumors, expressed specifically in Leydig cell tumors (at protein level). Expressed from 14 weeks until birth in fetal testis.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Black mamba toxin related protein antibody
    • EG VEGF antibody
    • EG-VEGF antibody
    • EGVEGF antibody
    • Endocrine-gland-derived vascular endothelial growth factor antibody
    • Mambakine antibody
    • PK1 antibody
    • PRK1 antibody
    • PROK1 antibody
    • PROK1_HUMAN antibody
    • Prokineticin-1 antibody
    see all

图片

  • ab42802 at 0.33 µg/ml staining Prokinectin 1 in tissue of chorionic villi at 9 weeks of gestation. Staining can be observed in Cytotrophoblast (Cyt), Hobfauer cells (Ho), Extravillous trophoblast (Evt) and Syncytiotrophoblast (St). Negative control with preimmune serum shows no staining. Counterstaining performed with haematoxylin.

文献

ab42802 has not yet been referenced specifically in any publications.

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