Anti-Prohormone convertase 1 + 2 + 3抗体(ab54084)

概述

  • 产品名称
    Anti-Prohormone convertase 1 + 2 + 3抗体
  • 描述
    兔多克隆抗体to Prohormone convertase 1 + 2 + 3
  • 特异性
    Prohormone convertase 1/2/3 consensus sequence.
  • 经测试应用
    适用于: ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide: NDPMFNKQWYL, corresponding to the consensus sequence region of the native molecule conjugated to Keyhole limpet Haemocyanin.

性能

应用

Our Abpromise guarantee covers the use of ab54084 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
  • 应用说明
    ELISA: Use at an assay dependent dilution.
    Does not displace peptide in range 0.1-1000 µg/ml, with 1 µg/well of pep-BSA coated.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性
      Prohormone Convertase 1 (PC1) is a serine proteinase responsible for the proteolytic processing of many precursor proteins within the regulated secretory pathway. The activity of PC1 is potentially regulated by two endogenous inhibitors, the PC1 propeptide and proSAAS. Prohormone Convertase 2 (PC2) is a subtilisin-like proprotein convertase, which is expressed extensively in mammalian neural and endocrine cells. PC2 plays a major role in the proteolytic processing of both neuropeptide and peptide hormone precursors. PC2 is expressed at high levels in the islets of Langerhans, where it participates in the processing of proinsulin to insulin. Prohormone convertase 3 (PC3) is a neuroendocrine-specific member of the subtilisin-kexin family, involved in the intracellular processing and maturation of prohormones and proneuropeptides.
    • 细胞定位
      PC1 and PC2: Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules. PC3: Golgi apparatus, trans-Golgi network. Note=Seems to be localized intracellularly to the trans Golgi network. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). Second cleavage in the propeptide occur in the trans Golgi network (TGN), which is followed by the release of the propeptide bound to furin and the activation of furin.
    • 数据库链接
    • 别名
      • FUR antibody
      • NEC1 antibody
      • NEC2 antibody
      • PACE antibody
      • PC1 antibody
      • PC2 antibody
      • PC3 antibody
      • PCSK3 antibody
      • prohormone convertase 1 antibody
      • prohormone convertase 3 antibody
      • SPC1 antibody
      • SPC2 antibody
      • SPC3 antibody
      see all

    文献

    ab54084 has not yet been referenced specifically in any publications.

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