概述

  • 产品名称Anti-PRODH抗体
    参阅全部 PRODH 一抗
  • 描述
    山羊多克隆抗体to PRODH
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    ERDGSGTNKRDKQYQ

    with a cysteine residue linker, corresponding to internal sequence amino acids 168 - 182 of Human PRODH (O43272)

  • 阳性对照
    • Human brain cerebellum, colon and liver tissue

性能

应用

Our Abpromise guarantee covers the use of ab113958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/16000.
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Converts proline to delta-1-pyrroline-5-carboxylate.
  • 组织特异性Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
  • 通路Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
  • 疾病相关Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome.
    Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • 序列相似性Belongs to the proline oxidase family.
  • 细胞定位Mitochondrion matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HSPOX2 antibody
    • mitochondrial antibody
    • P53 induced gene 6 protein antibody
    • p53-induced gene 6 protein antibody
    • PIG6 antibody
    • POX antibody
    • PROD_HUMAN antibody
    • PRODH 1 antibody
    • PRODH 2 antibody
    • PRODH antibody
    • PRODH1 antibody
    • PRODH2 antibody
    • Proline dehydrogenase antibody
    • proline dehydrogenase (oxidase) 1 antibody
    • proline dehydrogenase (proline oxidase) antibody
    • Proline dehydrogenase 1 antibody
    • Proline dehydrogenase 1, mitochondrial antibody
    • Proline oxidase 1 antibody
    • Proline oxidase 2 antibody
    • Proline oxidase antibody
    • Proline oxidase, mitochondrial antibody
    • Proline oxidase, mitochondrial precursor antibody
    • SCZD4 antibody
    • TP53I6 antibody
    • tumor protein p53 inducible protein 6 antibody
    see all

Anti-PRODH antibody 图像

  • ab113958 at 3.75 ug/ml, staining PRODH in Formalin-fixed, Paraffin-embedded Human brain cerebellum by Immunohistochemistry.
  • ab113958 at 3.75 ug/ml, staining PRODH in Formalin-fixed, Paraffin-embedded Human colon tissue by Immunohistochemistry.
  • ab113958 at 3.75 ug/ml, staining PRODH in Formalin-fixed, Paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-PRODH antibody (ab113958)参考文献

ab113958 has not yet been referenced specifically in any publications.

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