Anti-proCathepsin D抗体[AF4G5] (ab119710)

概述

  • 产品名称
    Anti-proCathepsin D抗体[AF4G5]
    参阅全部 proCathepsin D 一抗
  • 描述
    小鼠单克隆抗体[AF4G5] to proCathepsin D
  • 经测试应用
    适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant Human proCathepsin D purified from E.coli with His tag.

  • 阳性对照
    • MCF7, HepG2 and SK-BR3 cell lysates.
  • 常规说明

    This product was changed from ascites to tissue culture supernatant on 18th September 2017. Lot numbers higher than GR155210 will be from tissue culture supernatant.

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

性能

应用

Our Abpromise guarantee covers the use of ab119710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 45 kDa.
IP Use at an assay dependent concentration.

Use at 1μg

靶标

  • 功能
    Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
  • 疾病相关
    Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
  • 序列相似性
    Belongs to the peptidase A1 family.
  • 细胞定位
    Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CATD_HUMAN antibody
    • cathepsin D (lysosomal aspartyl protease) antibody
    • Cathepsin D antibody
    • Cathepsin D heavy chain antibody
    • Ceroid-lipofuscinosis, neuronal 10 antibody
    • CLN10 antibody
    • CPSD antibody
    • ctsd antibody
    • EC 3.4.23 antibody
    • EC 3.4.23.5 antibody
    • Lysosomal aspartyl peptidase antibody
    • Lysosomal aspartyl protease antibody
    • MGC2311 antibody
    • OTTHUMP00000042282 antibody
    • OTTHUMP00000196039 antibody
    • OTTHUMP00000198692 antibody
    see all

Anti-proCathepsin D antibody [AF4G5] 图像

  • All lanes : Anti-proCathepsin D antibody [AF4G5] (ab119710) at 1/2000 dilution

    Lane 1 : MCF7 cell lysate
    Lane 2 : SK-BR3 cell lysate


    Predicted band size : 45 kDa

实验方案

Anti-proCathepsin D antibody [AF4G5] (ab119710)参考文献

ab119710 has not yet been referenced specifically in any publications.

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