概述

  • 产品名称
  • 描述
    兔多克隆抗体to proBNP
  • 特异性
    ab32842 recognises Pro-Brain Natriuretic Peptide.
  • 经测试应用
    适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human proBNP aa 104-123.
    Sequence:

    PKMVQGS GCFGRKMDRI SSS

性能

应用

Our Abpromise guarantee covers the use of ab32842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 16-18 kDa.
IP 1/200. (1µl/250µg protein extract)

靶标

  • 功能
    Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
  • 组织特异性
    Brain and also in atria, but at much lower levels than ANP.
  • 序列相似性
    Belongs to the natriuretic peptide family.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANFB_HUMAN antibody
    • BNP antibody
    • BNP(1-32) antibody
    • BNP(5-29) antibody
    • BNP-32 antibody
    • Brain type natriuretic peptide antibody
    • Gamma brain natriuretic peptide antibody
    • Gamma-brain natriuretic peptide antibody
    • Natriuretic peptide precursor B antibody
    • nppb antibody
    • NT proBNP antibody
    see all

Anti-proBNP antibody (ab32842)参考文献

This product has been referenced in:
  • Li L  et al. Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure. J Mol Cell Cardiol : (2012). WB ; Mouse . Read more (PubMed: 22921782) »
  • Zhan DY  et al. Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation. Cardiovasc Res 84:64-71 (2009). Read more (PubMed: 19477965) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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