概述

  • 产品名称Anti-proBNP抗体[15F11]
    参阅全部 proBNP 一抗
  • 描述
    小鼠单克隆抗体[15F11] to proBNP
  • 经测试应用适用于: ELISA, WB, IP, Sandwich ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    ETSGLQEQRNHLQGK

    , corresponding to amino acids 13 - 27 of Human proBNP.

  • 常规说明Immunoglobulin concentrations vary from batch to batch. Please contact technical services for the latest information.

性能

应用

Our Abpromise guarantee covers the use of ab13115 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Detects a band of approximately 13 kDa.
IP Use at an assay dependent concentration. PubMed: 21482747
Sandwich ELISA Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [24E11] to proBNP (HRP) (ab13123). Can be used as capture antibody in conjunction with recommended pair. Recognises the antigen in blood of patients with heart faliure, unstable angina and myocardial infarction.

靶标

  • 功能Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
  • 组织特异性Brain and also in atria, but at much lower levels than ANP.
  • 序列相似性Belongs to the natriuretic peptide family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANFB_HUMAN antibody
    • BNP antibody
    • BNP(1-32) antibody
    • BNP(5-29) antibody
    • BNP-32 antibody
    • Brain type natriuretic peptide antibody
    • Gamma brain natriuretic peptide antibody
    • Gamma-brain natriuretic peptide antibody
    • Natriuretic peptide precursor B antibody
    • nppb antibody
    • NT proBNP antibody
    see all

Anti-proBNP antibody [15F11] (ab13115)参考文献

This product has been referenced in:
  • Tonne JM  et al. Secretion of glycosylated pro-B-type natriuretic peptide from normal cardiomyocytes. Clin Chem 57:864-73 (2011). IP ; Human . Read more (PubMed: 21482747) »

See 1 Publication for this product

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Thank you very much for your inquiry.

I have to confirm that do not have any pro-BNP antibodies that are tested and guaranteed for rat.

I checked the immunogens for the available pro-BNP antibodies and unfortunately I cannot recomme...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"