Anti-Probable hydrolase PNKD抗体(ab113811)

概述

  • 产品名称Anti-Probable hydrolase PNKD抗体
    参阅全部 Probable hydrolase PNKD 一抗
  • 描述
    兔多克隆抗体to Probable hydrolase PNKD
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Goat, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N-terminal amino acids 1-50 (

    MAAVVAATALKGRGARNARVLRGILSGATANKASQNRTRALQSHSSPECK

    ) of Mouse PNKD (NP_079856).

  • 阳性对照
    • Mouse heart lysate

性能

应用

Our Abpromise guarantee covers the use of ab113811 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway.
  • 组织特异性Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only.
  • 疾病相关Defects in PNKD are the cause of dystonia type 8 (DYT8) [MIM:118800]. DYT8 is a paroxysmal non-kinesigenic dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT8 is characterized by attacks of involuntary movements brought on by stress, alcohol, fatigue or caffeine. The attacks generally last between a few seconds and four hours or longer. The attacks may begin in one limb and spread throughout the body, including the face.
  • 序列相似性Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  • 翻译后修饰Isoform 2 is phosphorylated at Ser-121 upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm. Nucleus; Mitochondrion and Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2210013N15Rik antibody
    • 2810403H05Rik antibody
    • AI854243 antibody
    • BRAIN PROTEIN 17 antibody
    • BRP17 antibody
    • DYT8 antibody
    • FKSG19 antibody
    • FPD1 antibody
    • KIAA1184 antibody
    • KIPP1184 antibody
    • MNCb-5687 antibody
    • MR-1 antibody
    • MR1 antibody
    • Myofibrillogenesis regulator 1 antibody
    • Paroxysmal nonkinesiogenic dyskinesia protein antibody
    • PDC antibody
    • PKND1 antibody
    • Pnkd antibody
    • PNKD_HUMAN antibody
    • Probable hydrolase PNKD antibody
    • TAHCCP2 antibody
    • Trans-activated by hepatitis C virus core protein 2 antibody
    see all

Anti-Probable hydrolase PNKD antibody 图像

  • Anti-Probable hydrolase PNKD antibody (ab113811) at 1 µg/ml + mouse heart lysate at 10 µg

    Predicted band size : 43 kDa

Anti-Probable hydrolase PNKD antibody (ab113811)参考文献

ab113811 has not yet been referenced specifically in any publications.

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