概述

  • 产品名称Anti-PRMT6抗体
    参阅全部 PRMT6 一抗
  • 描述
    兔多克隆抗体to PRMT6
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Horse, Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region within C terminal amino acids 325-375 of Human PRMT6 (AAK85733.1).

  • 阳性对照
    • Human breast, colon, ovarian and prostate carcinoma tissues; non small cell lung cancer tissue; stomach adenocarcinoma and testicular seminoma tissues. Mouse colon carcinoma CT26, renal cell carcinoma and teratoma tissues

性能

应用

Our Abpromise guarantee covers the use of ab93877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    Epitope exposure is recommended. Epitope exposure with tris EDTA pH 9.0 buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).
    • 组织特异性Highly expressed in kidney and testis.
    • 序列相似性Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT6 subfamily.
      Contains 1 SAM-dependent MTase PRMT-type domain.
    • 翻译后修饰Automethylation enhances its stability and antiretroviral activity.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ANM6_HUMAN antibody
      • Chromobox protein homolog 7 antibody
      • FLJ10559 antibody
      • FLJ51477 antibody
      • Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6 antibody
      • Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 antibody
      • Histone-arginine N-methyltransferase PRMT6 antibody
      • HMT1 hnRNP methyltransferase like 6. antibody
      • HRMT1L6 antibody
      • OTTHUMP00000012633 antibody
      • PRMT 6 antibody
      • prmt6 antibody
      • Protein arginine methyltransferase 6 antibody
      • Protein arginine N methyltransferase 6 antibody
      • Protein arginine N-methyltransferase 6 antibody
      see all

    Anti-PRMT6 antibody 图像

    • ab93877, at a 1/250 dilution, staining PRMT6 in formalin fixed, paraffin embedded Human colon carcinoma tissue by Immunohistochemistry. Detection: DAB staining.
    • ab93877, at a 1/250 dilution, staining PRMT6 in formalin fixed, paraffin embedded Mouse teratoma tissue by Immunohistochemistry. Detection: DAB staining.

    Anti-PRMT6 antibody (ab93877)参考文献

    ab93877 has not yet been referenced specifically in any publications.

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