All tags Primary Antibodies Human CD antigen chart

Human CD antigen chart

The cluster of differentiation (CD) nomenclature system was conceived to classify antigens found on the surface of leukocytes.

Initially, surface antigens were named after the monoclonal antibodies that bound to them. As there were often multiple monoclonal antibodies raised against each antigen by different labs, the need arose to adopt a consistent nomenclature. The current system was adopted in 1982, during the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA) in Paris. 

Under the current naming system, antigens that are well characterized are assigned an arbitrary number (e.g. CD1, CD2 etc) whereas molecules that are recognised by just one monoclonal antibody are given the provisional designation “CDw”. Physiologically, CD antigens do not belong in any particular class of molecules, with their functions ranging from cell surface receptors to adhesion molecules. Although initially used just for human leukocytes, the CD molecule naming convention has now been expanded to cover both other species (e.g. mouse) as well as other cell types. Human CD antigens are currently numbered up to CD363.

The presence or absence of a specific antigen from the surface of particular cell population is denoted with “+” or “-" respectively. Varying cellular expression levels are also marked as hi or low, for example central memory T cells are CD62Lhi whereas effector memory T cells are CD62Llow. Monitoring the expression profiles of different CD antigens has permitted the identification, isolation and phenotyping of cell types according to their function in various immune processes.

Use the table below to find your target of interest. You can click on each target for more products information.

Download your Human CD Antigen Guide pdf.


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Target NameAlternative NameCellular ExpressionFunctions
CD1a-                                        ​Cortical thymocytes, Langerhans cells, dendritic cells and certain T-cell leukemias.Non-peptide antigen presentation to T-cell receptors on NKT cells, marks T-cells at the short cortical thymic stage of differentiation.
CD1b-Cortical thymocytes, Langerhans cells and dendritic cells.

Non peptide antigen presentation to  T-cell receptors on NKT cells.

CD1c-Cortical thymocytes, Langerhans cells, dendritic cells and B-cell subsets.Non peptide antigen presentation to T-cell receptors on NKT cells.
CD1dR3G1Intestinal epithelial cells, B-cell subsets, cortical thymocytes, dendritic cells and certain T-cell leukemias.Non peptide antigen presentation to T-cell receptors on NKT cells.
CD1eR2G1Cortical thymocytes, Langerhans cells, dendritic cells and certain T-cell leukemias.Non peptide antigen presentation.
CD2SRBC, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptorThymocytes, natural killer cells, T- and B-cells.Adhesion between T-cells and other cell types and T-cell activation.
CD3dT3D, OKT3Mature T-cells and thymocytes.T-cell activation signaling and regulation of TCR expression.
CD3eT3E, TCREMature T-cells and thymocytes.T-cell activation signaling and regulation of TCR expression.
CD3gT3GMature T-cells and thymocytes.T-cell activation signaling and regulation of TCR expression.
CD4
Thymocyte subsets, T-helper cells, regulatory T-cells, monocytes and macrophages.T-cell activation, thymic differentiation and receptor for HIV.
CD5LEU1Thymocytes, T- and B-cell subsets and B-cell chronic lymphocytic leukemia cells.Regulates T-cell: B-cell interactions. Interacts with CD72.
CD6OX52, T12, TP120Thymocytes, T- and B-cell subsets and neuron subsets.Thymocyte development, a potential market of T-cell activation.
CD7LEU 9, GP40, TP41Thymocytes, T-cells, natural killer cells and pluripotent hematopoietic stem cells.T-cell costimulation. Interacts with SECTM1.
CD8aMALThymocyte subsets, cytotoxic T-cells, natural killer cells and dendritic cells subsets.Co-receptor for MHC class 1 molecules.
CD8bCD8B1Thymocyte subsets and cytotoxic T-cells.Co-receptor for MHC class 1 molecules.
CD9P24, 5H9 antigen, MIC3, TSPAN29, GIG2Platelets, pre-B-cells, eosinophils, basophils, activated T-cells, endothelial cells and epithelial cells.Cell adhesion and migration, platelet activation and aggregation.
CD10Neprilysin, CALLA, SFE, MME, EPNB- and T-cell precursors, fibroblasts, neurons and bone marrow stromal cells.Peptidase, regulates B-cell growth.
CD11aIntegrin alpha-L, LFA-1A, ITGALLeukocytes, lymphocytes, granulocytes, monocytes and macrophages.Intracellular adhesion and costimulation.
CD11bIntegrin alpha-M, CR3A, ITGAMGranulocytes, monocytes, natural killer cells, T- and B-cells and dendritic cells.Cell adhesion, apoptosis and chemotaxis.
CD11cIntegrin alpha-X, Leu M5, ITGAXMonocytes, macrophages, granulocytes, T- and B-cell subsets.Cell adhesion.
CD11dIntegrin-alpha-D, ADB2, ITGADMyelomonocytic cells, peripheral blood leukocyte subsets and tissue-specialized cellsReceptor for ICAM3 and VCAM1. May play a role in atherosclerotic process and phagocytosis of blood-borne pathogens.
CD13Aminopeptidase N, ANPEP, APN, PEPNGranulocytes, monocytes (+ precursors), endothelial cells and epithelial cells.Zinc binding metalloproteinase.
CD14
Monocytes, macrophages (myelomoncytic cells), Langerhans cells and granulocytes.Receptor for complex of LPS and LBP.
CD153-FAL, ELAM 1 ligand, fucosyltransferase, Leu M1Granulocytes, monocytes, neutrophils and eosinophils.Cell adhesion. Mediates phagocytosis and chemotaxis.
CD16aFc-gamma RIII-alpha, FCGR3A, FCG3, FCGR3, IGFR3Neutrophils, natural killer cells and macrophages.Low affinity Fc receptor. Mediates phagocytosis and ADCC.
CD16bFc-gamma RIII-beta, FCGR3B, FCG3, FCGR3, IGFR3Neutrophils and stimulated eosinophils.Low affinity Fc receptor.
CD17LactosylceramideMonocytes, platelets, B-cell subsets, granulocytes, dendritic cells, T-cells, platelets, neutrophils and thrombocytes.Lactocyl ceramide. Cell surface glycosphingolipid. May play a role in bacterial phagocytosis.
CD18Integrin beta-2, ITGB2, MFI7Leukocytes.Forms the beta 2 chain of CD11a-c, cell adhesion.
CD19B-lymphocyte surface antigen B4, T-cell surface antigen Leu-12B-cells (but not plasma cells) and follicular dendritic cells.Regulates B-cell development, activation and differentiation. Signal transduction.
CD20B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, MS4A1T- and B-cell subsets.B-cell activation and proliferation.
CD21Complement receptor type 2, CR2, C3DR, Complement C3d receptor, Epstein-Barr virus receptorMature B-cells, follicular dendritic cells and T-cell subsets.Signal transduction. Receptor for complement components C3Dd and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220.
CD22SIGLEC2, BL-CAM, T-cell surface antigen Leu-14Mature B-cells.B-cell adhesion and signal transduction.
CD23Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, Fc epsilon RII, FCER2, CLEC4JMature B-cells, activated macrophages, eosinophils, follicular dendritic cells and platelets.Low affinity receptor for IgE, ligand for CD19, CD21 and CD81.
CD24NectadrinB-cells, granulocytes, epithelial cells and monocytes.Regulation of B-cell proliferation and differentiation.
CD25Interleukin-2 receptor subunit alpha, IL2RA, TAC antigenActivated T- and B-cells, some thymocytes, pre B-cells, regulatory T-cells, and oligodendrocytes.Receptor for IL2.
CD26Dipeptidyl peptidase 4, DPP4 , ADABP, ADCP2Mature thymocytes, T-cells (upregulated on activation), activated B-cells, natural killer cells, epithelial cells and macrophages.Exoprotease. HIV pathogenesis.
CD27TNF receptor superfamily member 7, TNFRSF 7, CD27L receptor, T14T-cells, medullary thymocytes, B-cell subsets and natural killer cells.Costimulation of B- and T-cell activation.
CD28TP44Most T-cells, thymocytes, plasma cells, natural killer cells and activated B-cells.Costimulation of T-cells. Induces T-cell activation and survival, interleukin-2 production, T-helper type 2 cell development and clonal expansion.
CD29Integrin beta-1, ITGB1, Fibronectin receptor subunit beta, FNRBLeukocytes.Interacts with CD49a in VLA-1 integrin. Lymphocyte and endothelial adhesion, lymphocyte trafficking and transvascular migration. Promotes or inhibits apoptosis (depending on stimulus).
CD30TNF receptor superfamily member 8, TNFRSF8, Ki-1 antigenActivated T- and B-cells, monocytes, activated natural killer cells and Reed-Sternberg cells.Regulates lymphocyte proliferation and cell death. Has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas.
CD31Platelet endothelial cell adhesion molecule, PECAM1Monocytes, platelets, granulocytes, endothelial cells, lymphocyte subsets and epithelial cells.Cell adhesion. Plays a key role in leukocyte trafficking across endothelium.
CD32Fc gamma RII, FCGR2A, FCGR2BB-cells, monocytes, granulocytes, platelets and endothelial cells.Regulation of B-cell function. Induces phagocytosis and mediator release.
CD33Sialic acid-binding Ig-like lectin 3, SIGLEC3Monocytes, granulocytes, mast cells and myeloid progenitors.Lectin activity and adhesion. A receptor that inhibits the proliferation of normal and leukemic myeloid cells.
CD34
Hematopoietic stem cells and progenitors and capillary endothelial cells.Cell adhesion (via L-selectin).  Possible role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells.
CD35Complement receptor type 1, C3b/C4b receptorErythrocytes, B-cells, monocytes, neutrophils, eosinophils, follicular dendritic cells and T-cell subsets.Receptor for complement components C3b and C4b. Mediates adhesion and phagocytosis.
CD36Platelet glycoprotein 4, Fatty acid translocase, Glycoprotein IIIb, GP3B, GP4Platelets, monocytes, macrophages, endothelial cells and thyroid precursors.Scavenger receptor preferentially found within lipid rafts. Mediates adhesion and phagocytosis.
CD37Tetraspanin 26, TSPAN26Mature B-cells and myeloid cells. Low level of expression in T-cells, granulocytes and monocytes.Signal transduction. Regulates T-cell proliferation.
CD38ADP ribosyl cyclase 1Variable expression levels on most hematopoietic and some non-hematopoietic cells. High levels on plasma cells, early T- and B-cells, activated T-cells and germinal centre B-cells.Regulates cell activation, proliferation and adhesion.
CD39NTPDase 1, ENTPD1Macrophages, Langerhans cells, dendritic cells, activated B-cells, natural killer cells and microglial cells.B-cell adhesion. Protects activated cells from lysis.
CD40TNF receptor superfamily member 5, TNFRSF5B-cells, monocytes, macrophages, follicular dendritic cells, endothelial cells, fibroblasts and keratinocytes.Costimulation of B-cell growth. Differentiation and isotype switching.
CD41Integrin alpha-IIb, GPalpha IIb, ITGA2B, GP2BPlatelets and megakaryocytes.Platelet activation and aggregation.
CD42aPlatelet glycoprotein IX, GP9Platelets and megakaryocytes.Platelet adhesion and aggregation. Amplifies platelet response to thrombin.
CD42bPlatelet glycoprotein Ib alpha chain, GP1BAPlatelets and megakaryocytes.Platelet adhesion and aggregation.
CD42cPlatelet glycoprotein Ib beta chain, GP1BBPlatelets and megakaryocytes.Platelet adhesion and aggregation.
CD42dPlatelet glycoprotein V, GP5Platelets and megakaryocytes.Platelet adhesion and aggregation.
CD43Leukosialin, Galactoglycoprotein, Leukocyte sialoglycoprotein, SPNLeukocytes (except resting B-cells). Low expression in platelets.Anti-adhesion. Binds CD45 to mediate adhesion.
CD44Epican, HUTCH-I, LHR, PGP-1, ECMR-IIIMost lymphohematopoietic cells.Leukocyte rolling, homing and aggregation. Adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix. Important in epithelial cell adhesion (cell-cell and cell-matrix) to hyaluronate in basement membranes, and maintaining polar orientation of cells.
CD45Leukocyte common antigen, L-CA, PTPRCHematopoietic cells (not erythrocytes and platelets).Critical for B- and T-cell receptor mediated activation. Also required for thymic selection.
CD45RA
B- and naïve T-cell subsets, monocytes and medullary thymocytes.Critical for B- and T-cell receptor mediated activation. Also required for thymic selection.
CD45RB
T-cell subsets, B-cells, monocytes, macrophages, granulocytes, dendritic cells and natural killer cells.Critical for B- and T-cell receptor mediated activation.

CD45RC

B-cells, natural killer cells, CD8+ T-cells, CD4+ T-cell subsets, medullary thymocytes, monocytes and dendritic cells.Critical for B- and T-cell receptor mediated activation.
CD45RO
Activated T-cell subsets, memory B- and T-cell subsets, monocytes, macrophages, granulocytes, cortical thymocytes and dendritic cell subsets.Critical for B- and T-cell receptor mediated activation.
CD46Membrane cofactor protein, TLX, MCPUbiquitous except erythrocytes.Co-factor for factor 1 proteolytic cleavage of C3b and C4b. Sets protective barrier threshold against inappropriate complement activation.
CD47Integrin associated protein, MER6Hematopoietic cells, epithelial cells, endothelial cells and mesechymal cells.Adhesion. A marker of self which binds to SIRP alpha inhibitor receptor on macro and dendritic cells to inhibit phagocytosis. Regulates chemotaxis and activation of leukocytes.
CD48BLAST1, BCM1Leukocytes.Cell adhesion and T-cell costimulation.
CD49aIntegrin alpha-1, VLA-1, ITGA1Activated T-cells, monocytes, melanoma cells and endothelial cells.Adhesion and embryo development.
CD49bIntegrin alpha-2, VLA-2 subunit alpha, ITGA2Platelets, B-cells, monocytes, activated T-cells, epithelial cells, endothelial cells, natural killer cell subsets and megakaryocytes.Adhesion and platelet aggregation. Receptor for echovirus 1.
CD49cIntegrin alpha-3, VLA-3 subunit alpha, ITGA3Most adhesion cell lines. Low expression on B- and T-cells. Adhesion and signal transduction.
CD49dIntegrin alpha-4, VLA-4 subunit alpha, ITGA4B- and T-cells, thymocytes, monocytes, eosinophils, basophils, natural killer cells, mast cells, dendritic cells and erythroblastic precursors.Adhesion, cell migration, homing and activation.
CD49eIntegrin alpha-5, VLA-5, ITGA5Thymocytes, T-cells, monocytes, platelets, early and activated B-cells, endothelial cells and epithelial cells.Adhesion, regulation of cell survival and apoptosis.
CD49fIntegrin alpha-6, VLA-6, ITGA6Memory B-cells, T-cells, thymocytes, monocytes, platelets, megakaryocytes, epithelial cells, endothelial cells and cytotrophoblasts.Embryogenesis, adhesion and cell migration. 
CD50ICAM3Leukocytes, thymocytes, Langerhans cells, endothelial cells, B- and T-cells, granulocytes and monocytes.Adhesion and costimulation.
CD51Integrin alpha chain V, ITGAV, MSK8Platelets, activated T-cells, endothelial cells, osteoblasts, melanoma cells and megakaryocytes.Adhesion and signal transduction.
CD52Campath-1, HE5Thymocytes, lymphocytes (not plasma cells), monocytes, macrophages and epithelial cells.Glycosylphosphatidylinositol (GPI) anchored antigen which may play a role in carrying and orienting carbohydrate.
CD53Tetraspanin-25, MOX44Leukocytes, dendritic cells, osteoblasts and osteoclasts.Signal transduction.
CD54ICAM1Endothelial cells, monocytes, hematopoietic and non-hematopoietic cells. Low expression on resting lymphocytes, upregulated on activation.Extravasation of leukocytes from blood vessels. Regulates T-cell activation.
CD55Complement decay accelerating factor, DAFEpithelial cells and all cells that are in close contact with plasma complement proteins.Regulates complement activation. Ligand or protective molecule in fertilization. Signal transduction.
CD56NCAM1Neural tissues, natural killer cells, T-cell subsets, small cell lung carcinoma.Homophilic and heterophilic adhesion.
CD57Human natural killer 1, HNK1, LEU7Natural killer cell subsets, T-cell subsets and monocytes.Adhesion.
CD58LFA3Leukocytes, erythrocytes, epithelial cells, endothelial cells, fibroblasts, hematopoietic and non-hematopoietic cells.APC-T-cell adhesion. Killer target cell interaction. Costimulation of CD58+ and CD2+ T-cells.
CD59Protectin, MAC-inhibitory proteinHematopoietic and non-hematopoietic cells.Prevents complement polymerization. Protects cells from complement mediated lysis.
CD60aCDw60, GD3Subsets of CD4+ and CD8+ peripheral T-cells, platelets and monocytes.The CD60 family are oligosaccharides present on gangliosides and are involved in co-stimulation of T-cells.
CD60bUM4D4, 9-O-acetyl-GD3Subsets of CD4+ and CD8+ peripheral T-cells, platelets and monocytes.The CD60 family are oligosaccharides present on gangliosides and are involved in co-stimulation of T-cells.
CD60c7-O-acetyl-GD3Subsets of CD4+ and CD8+ peripheral T-cells, platelets and monocytes.The CD60 family are oligosaccharides present on gangliosides and are involved in co-stimulation of T-cells.
CD61Integrin beta-3, ITGB3, GP3AWith CD41 on platelets, with CD51 on macrophages, endothelial cells, fibroblasts, megakaryocytes, osteoclasts, mast cells and macrophages.Mediates cell adhesion to diverse matrix proteins.
CD62EE-selectin, SELE, ELAM1Activated endothelial cells.Leukocyte rolling and adhesion to activated endothelium at inflammatory sites. Tumor cell adhesion and angiogenesis.
CD62LL-selectin, SELL, LAM1B- and T-cell subsets, monocytes, granulocytes, natural killer cells and thymocytes.Leukocyte rolling and homing on activated endothelium.
CD62PP-selectin, SELP, LECAM3Activated platelets, endothelial cells and megakaryocytes.Leukocyte tethering and rolling on the surface of activated endothelial cells.
CD63LAMP-3, Granulophysin, MLA1Activated platelets, monocytes, macrophages, granulocytes and endothelial cells.Translocated to cell surface on activation of platelets, endothelial cells and granulocytes. Associated with the early stages of melanoma tumor progression (in regulation of motility and adhesion of melanoma cells).
CD64IgG Fc receptor I, FCGR1AMonocytes and macrophages.Binds to the Fc region of IgG with high affinity.
CD65VIM2Granulocytes and myeloid cells. Low expression on monocytes.Adhesive carbohydrate. 
CD66aCEACAM1, Biliary glycoprotein 1Mature granulocytes, epithelial cells, hematopoietic tissues, neutrophils, colon and liver.Neutrophil activation, homophilic and heterophilic adhesion.
CD66bCEACAM8, CD67, CGM6Granulocytes.Cell adhesion and neutrophil activation.
CD66cCEACAM6, NCANeutrophils, epithelial cells and colon carcinoma.Cell adhesion and neutrophil activation.
CD66dCEACAM3, CGM1Neutrophils.Cell adhesion and neutrophil activation.
CD66eCEACAM5, CEAAdult colon epithelial cells and colon carcinoma.Homophilic and heterophilic adhesion. May play a role in the metastasis of cancer cells.

CD66f
Pregnancy-specific beta-1-glycoprotein 1, PSG1, PSBG1Eptihelial cells, placental syncytiotrophoblasts and fetal liver.Immune regulation and protection of fetus from maternal immune system.
CD67 See CD66b

CD68Macrosialin, KP1Monocytes, macrophages, neutrophils, basophils, dendritic cells and myeloid progenitors.Possibly has a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. May allow macrophages to crawl over selectin bearing substrates or other cells.
CD69Activation inducer molecule, AIM, CLEC2C, EA1Activated leukocytes, natural killer cells, thymocyte subsets, platelets, Langerhans cells and activated macrophages.Signal transmitting receptor.  Involved in early events of T-cell, natural killer cell, monocyte and platelet activation.
CD70CD27 ligand, CD27LActivated B- and T-cells and macrophages.Induces proliferation of costimulated T-cells. Enhances the generation of cytotoxic T-cells and contributes to T-cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells and immunoglobulin synthesis.
CD71Transferrin receptor protein 1, TFRCProliferating cells, reticulcytes, erythroid precursors and activated leukocytes.Controls iron uptake during cell proliferation.
CD72Lyb-2, Ly-19, Ly-32B-cells (but not plasma B-cells), macrophages, follicular dendritic cells, epithelial cells and endothelial cells.B-cell activation and proliferation.
CD735'-nucleotidase, NT5EB- and T-cell subsets, dendritic reticulium cells, epithelial cells and endothelial cells.Nucleotidase. Dephosphorylates nucleotides to permit uptake of nucleosides.
CD74LN2, Ii, DHLAGB-cells, activated T-cells, macrophages, Langerhans cells, dendritic cells, endothelial cells and epithelial cells.Intracellular sorting of MHC class II molecules.
CD75ST6GAL1, Sialyltransferase 1B- and T-cell subsets and erythrocytes.Catalyzes the transfer of sialic acid from CMP sialic acid to galactose-containing substrates.  Cell adhesion.
CD75s
B- and T-cell subsets.CD75s differentiation antigens are cell-surface carbohydrate determinants generated by CD75.
CD77Globotriaosylceramide , BLAGerminal centre B-cells and macrophages. High expression in Burkitt’s lymphocytes.Induces apoptosis.
CD79aMB1, IGAB-cells.Subunit of B-cell antigen receptor (CD79a+CD79b).Signal transduction.
CD79bB29, IGBB-cells.Subunit of B-cell antigen receptor (CD79a+CD79b).Signal transduction.
CD80B7-1Activated B- and T-cells, macrophages and dendritic cells.Costimulation of T-cell activation and proliferation. Has a critical role in autoimmune, humoral, and transplant responses.
CD81TAPA1, Tetraspanin-28B- and T-cells, natural killer cells, monocytes, thymocytes, dendritic cells, endothelial cells and fibroblasts.Signal transduction. Facilitates complement recognition.
CD82KAI1, Tetraspanin-27Leukocytes (upregulated on activation) and platelets.Signal transduction.
CD83HB15Activated B- and T-cells, circulating dendritic cells and Langerhans cells.Regulates immune responses.
CD84SLAM5Mature B-cells, T-cell subsets, monocytes, macrophages, platelets and thymocytes.Homophilic adhesion molecule. Enhances T-cell activation and cytokine production.
CD85aLILRB3, ILT5, LIR3Monocytes, macrophages, myeloid cells, some T-cells, natural killer cells, basophils, eosinophils and B-cells.Inhibitory receptor for MHC class I molecules. Involved in natural killer cell mediated cytotoxicity.

CD85b
LILRA6, ILT8Monocytes, macrophages, T-cell and natural killer cell subsets, dendritic cells and B-cells.Involved in natural killer cell mediated cytotoxicity.
CD85cLILRB5, LIR8Natural killer cells.May act as receptor for class I MHC antigens.
CD85dLILRB2, ILT4, LIR2, MIR10Monocytes, macrophages, B- and T-cells, dendritic cells, eosinophils and natural killer cells.Receptor for class I MHC antigens. Down regulates the immune response and involved in the development of tolerance.
CD85eLILRA3, ILT6, LIR4B-cells, natural killer cells, peripheral blood monocytes and lung.May act as soluble receptor for class I MHC antigens.
CD85fLILRA5, ILT11, LIR9Hematopoitic cells, natural killer cells, B- and T-cells.Hematopoitic cells, natural killer cells, B- and T-cells.
CD85gLILRA4, ILT7Eosinophils, neutrophils, plasmacytoid dendritic cells and monocytes.May act as receptor for class I MHC antigens.
CD85hLILRA2, ILT1, LIR7Basophils, myeloid cells and plasmacytoid dendritic cells.May act as receptor for class I MHC antigens.
CD85iLILRA1, LIR6Monocytes and B-cells.May act as receptor for class I MHC antigens.
CD85jLILRB1, ILT2, LIR1B-cells, monocytes and dendritic cells.Receptor for class I MHC antigens. Transduces negative signals that prevent killing of MHC class I expressing cells. Receptor for CMV UL18 protein.
CD85kLILRB4, ILT3, LIR5Monocytes, macrophages, dendritic cells, endothelial cells, natural killer cells and B-cells.Receptor for class I MHC antigens. Involved in downregulation of immune response and development of tolerance, including transplants.
CD86CD28LG2, B7-2Monocytes, activated B- and T-cells and endothelial cells.Costimulation of T-cell activation and proliferation.
CD87UPAR, PLAUR, MO3Granulocytes, monocytes, natural killer cells, T-cells, endothelial cells, fibroblasts and hepatocytes.Cell chemotaxis and adhesion.
CD88C5R1, C5ARGranulocytes, monocytes, dendritic cells and astrocytes.Granulocyte activation.  Stimulates chemotaxis, granule enzyme release and superoxide anion production.
CD89FCARMonocytes, macrophages, granulocytes, neutrophils, B- and T-cell subsets.IgA Fc receptor (binds IgA and eliminates IgA coated targets). Induces phagocytosis, degranulation, respiratory burst and killing of micro-organisms.
CD90THY1Hematopoeitic cells, neuronal cells, fibroblasts, stromal cells and activated endothelial cells.Costimulation of lymphocytes. Possible inhibition of stem cell and neuron differentiation.
CD91LRP1, A2MR, APOERMonocytes, macrophages, neuronal cells and fibroblasts.Large scavenger receptor that mediates the uptake and degradation of various ligands.
CD92CTL1, SLC44A1B-cells, most T-cells, monocytes, natural killer cells, neutrophils, fibroblasts and endothelial cells.Intermediate-affinity, sodium independent choline transporter.
CD93C1qR, C1QR1, MXRA4Monocytes, granulocytes, endothelial cells and neutrophils.May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
CD94KLRD1, KP43Natural killer cells and T-cell subsets.Inhibition of natural killer cell function. Induces cytolytic activity and cytokine production.
CD95Apoptosis antigen ligand, FASLG, APTL, TNFSF6Monocytes, neutrophils, lymphocytes and fibroblasts.Induces apoptosis.
CD96TactileLow levels on peripheral T-cells. Strongly up-regulated after activation.Involved in adhesive interactions of activated T-cells and natural killer cells during the late phase of the immune response. Promotes natural killer cell target adhesion by interacting with PVR present on target cells. 
CD97
Granulocytes and monocytes. Low expression in lymphocytes, macrophages and dendritic cells.Neutrophil migration. May be involved in cell adhesion and signaling processes after leukocyte activation.
CD984F2hc, SLC3A2, MDU1Monocytes, lymphocytes natural killer cells and granulocytes.Cell activation and cell aggregation.
CD99MIC2Lymphocytes, natural killer cells, monocytes, granulocytes, endothelial cells, epithelial cells, some tumor cells and thymocytes.Leukocyte migration, T-cell activation and cell adhesion.
CD100Semaphorin 4D, SEMA4DLeukocytes and oligodendrocytes.Impairs monocytes migration. B- and T- activation. B-cell:T-cell interaction. T-cell:dendritic cell interaction.
CD101IGSF2, EWI101Monocytes, granulocytes, dendritic cells, activated T-cells and Langerhans cells.Inhibits T-cell activation and proliferation.
CD102ICAM2Resting lymphocytes, monocytes, platelets and vascular endothelial cells.Adhesion, costimulation and lymphocyte recirculation.
CD103Integrin alpha E, ITGAEIntra-epithelial lymphocytes, some peripheral blood lymphocytes and activated lymphocytes.Lymphocyte retention. Receptor for E-cadherin.
CD104Integrin beta 4, ITGB4Epithelial cells, endothelial cells, Shwann cells and keratinocytes.Adhesion receptor (for laminins) in normal epithelia. Migration and tumor metastasis.
CD105Endoglin, ENG, ENDEndothelial cells, mesenchymal stem cells, erythroid precursors, activated monocytes and macrophages.Angiogenesis. Regulatory component of TGF-beta receptor complex. Modulates cellular response to TGF beta 1.
CD106VCAM1, L1CAMActivated endothelial cells and follicular dendritic cells.Leukocyte adhesion. Transmigration and costimulation of T-cells.
CD107aLAMP1Activated platelets, activated T-cells, activated endothelial cells and activated granulocytes.Promotes adhesion of human PBMCs to vascular endothelium. Possibly involved in the adhesion of PBMCs to the site of inflammation.
CD107bLAMP2Activated platelets, activated T-cells and activated endothelial cells.May be involved in leucocyte adhesion. Important in autophagy. Implicated in tumor cell metastasis.
CD108Semaphorin 7A, SEMA7AActivated T-cells, erythrocytes, fibroblasts and monocytes.Monocyte activator. Negative regulator of T-cell responses. Stimulates axon growth and guidance during development.
CD109CPAMD7Activated T-cells, activated platelets, subset of CD34+ cells and endothelial cells.Modulates negatively TGFB1 signaling in keratinocytes.
CD110TPOR, MPLSubset of stem cells and cells of megakaryocytic lineage as well as platelets.Binding to thrombopoietin induces megakaryocyte proliferation and differentiation and prevents apoptosis.
CD111Nectin1, PVRL1, HVECSubset of stem cells, macrophages and neutrophils.Entry mediator for several herpesvirus (HSV1, HSV2, PRV, BHV1). Believed to be involved in cell adhesion mechanisms.
CD112Nectin2, PVRL2, HVEBSubset of stem cells, neutrophils, monocytes, subset of CD34+ cells, endothelial cells, epithelial cells and myeloid cells.Intracellular adhesion, component of adherins junctions. Receptor for herpes simplex virus.
CD113Nectin3, PVRL3 Testis and placental tissues.Adhesion molecule that interacts with afadin which connects nectin to the actin cytoskeleton.
CD114GCSFR, CSF3RMyeloid progenitor cells, endothelial cells and  trophoblastic cells.Myeloid cell proliferation and differentiation.
CD115CSF1R, FMSMonocytes, macrophages, monocytic progenitors, neuronal cells and osteoclasts.Monocytic cell proliferation and differentiation.
CD116GMR-alpha, CSF2RAMonocytes, macrophages, granulocytes, dendritic cells, endothelial cells and eosinophils.Myeloid cell hematopoiesis and differentiation.
CD117c-kit, KITHematopoietic stem cells and progenitors.Crucial for development of gonadal and pigment stem cells.
CD118LIFREpithelium cells.Regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion.
CD119IFNGR1Lymphocytes, natural killer cells, monocytes, macrophages, granulocytes, endothelial cells and epithelial cells.Receptor for interferon gamma. Role in host defense and immunopathological processes.
CD120aTNF Receptor I, TNFRSF1AHematopoietic and non-hematopoietic cells and epithelial cells.Receptor for TNF. Involved in cell differentiation, apoptosis and necrosis. Contributes to the induction of non-cytocidal TNF effects, including anti-viral state and activation of the acid sphingomyelinase.
CD120bTNF Receptor II, TNFRSF1BHematopoietic and non-hematopoietic cells and epithelial cells.Receptor for TNF. Involved in cell differentiation, apoptosis and necrosis.
CD121aIL-1R type I, IL1R1Fibroblasts, lymphocytes, monocytes, macrophages, granulocytes, dendritic cells. epithelial cells, and neural cells.Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling.
CD121bIL-1R type II, IL1R2B-cells, monocytes, macrophages, some T-cells and keratinocytes.Non-signaling receptor for IL1A, IL1B and IL1RN. Mediates negative signaling of IL1.
CD122IL2RBNatural killer cells, resting T-cells, B-cell subsets and monocytes.IL2 and IL15 receptor beta chain signaling.
CD123IL3RABasophils, eosinophils, hematopoietic progenitors, macrophages, dendritic cells, endothelial cells and a small subset of lymphocytes.Receptor for IL3. Associates with the GM-CSF receptor.
CD124IL4RA, IL4REndothelial cells, epithelial cells, fibroblasts, mature B- and T-cells. Low expression on leukocytes and progenitors.Receptor for IL4 and IL13.
CD125IL5RA, IL5REosinophils, basophils, activated B-cells and mast cells.Receptor for IL5.
CD126IL6R, gp80Activated B- and plasma cells, T-cells, monocytes, epithelial cells and fibroblasts.Receptor for IL6.
CD127IL7RB-cell precursors, mature T-cells, thymocytes and monocytes.Receptor for IL7.
CD128See CD181 and CD182.

CD129IL9RHematopoietic cells including T-cells, neutrophils, mast cells and macrophages.Receptor for IL9. Supports erythroid colony formation and synergizes with IL4 in the production of IgE and IgG.
CD130IL6ST, gp130T-cells, activated B-cells, plasma cells, monocytes and endothelial cells.Transmits activities of IL6, IL11, LIF and CNF.
CD131IL3RB, CSF2RBMonocytes, granulocytes, early B-cells and hematopoietic stem cells.Component of the high affinity IL3, GM-CSF and IL5 receptors.  Crucial role in growth / activation of eosinophils and in the inflammatory response. 
CD132IL2RGVariety of leukocytes including B- and T-cells, natural killer cells, monocytes, macrophages and neutrophils.Forms complexes with other cell surface proteins including CD25, CD122, CD124, CD127 and others. Complexes with other cell surface proteins to form receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the CD132 containing complexes, these cytokines regulate lymphocyte development and activation.
CD133Prominin-1, PROM1, AC133Hematopoietic stem cell subsets, epithelial, endothelial and neural cell precursors.Binds cholesterol in cholesterol-containing plasma membrane microdomains. Involved in regulation of MAPK and Akt signaling pathways. May play a role in apical plasma membrane organization of epithelial cells.
CD134TNFRSF4, OX40L receptorActivated  CD4+ and CD8+ T-cells, regulatory T-cells and B-cells.T-cell activation, proliferation and differentiation, apoptosis and cell adhesion.
CD135FLT3, FLK2Mutipotential, myelocytic monocytes and primitive B-cell progenitors.Receptor tyrosine kinase. Growth factor receptor. Binds FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells.
CD136RON, PTK8Expression documented in many normal human tissues, including normal colon, mouth, prostate and testis, as well as cancerous colon, prostate, stomach, and uterus.Mediates activity of macrophage-stimulating protein (MSP) which regulates cell adhesion, motility, growth, and survival. Implicated in the progression of several epithelial cancers.
CD137TNFRSF9, ILAActivated B- and T-cells, follicular dendritic cells, monocytes and epithelial cells.Costimulation of T-cell activation. Regulates T-cell-dependent immune responses.
CD138Syndecan, SDCPlasma cells, pre-B-cells, epithelial cells, neural cells and breast cancer cells.Expected to play a role in cell adhesion.
CD139
Germinal center B cells, follicular dendritic cells and follicular mantle.Unknown.
CD140aPDGFR-alpha, PDGFRAFibroblasts, mesenchymal cells, platelets, glial cells and chondrocytes.Cell proliferation, differentiation and survival.
CD140bPDGFR-beta, PDGFRBFibroblasts, mesenchymal cells, platelets, glial cells and chondrocytes.Cell proliferation, differentiation and survival.
CD141Thrombomodulin, THBDMonocytes, neutrophils, platelets and endothelial cells.Activation of protein C and initiation of protein C anti-coagulant pathway.
CD142Tissue factor, F3Monocytes, epithelial cells, astrocytes, Schwann cells and endothelial cells.Initiates blood clotting.
CD143Angiotensin Converting Enzyme 1, ACEEndothelial cells, epithelial cells, dendritic cells, neuronal cells and activated macrophages.Converts angiotensin I to angiotensin II by release of terminal His-Leu, which results in an increase of the vasoconstrictor activity of angiotensin.
CD144VE cadherin, Cadherin-5Endothelial cells and stem cell subsets.Cell adhesion.
CD146MCAM, MUC18Endothelial cells, follicular dendritic cells, activated T-cells and smooth muscle.Cell adhesion. Involved in heterophilic cell to cell interactions.
CD147Basigin, BSGLeukocytes, erythrocytes, platelets and endothelial cells.Cell adhesion and T-cell activation.
CD148DEP1, PTPRJGranulocytes, monocytes, dendritic cells, platelets, B- and T-cells.Tyrosine phosphatase cell signaling, cell growth and differentiation, mitotic cycle and oncogenic transformation.
CD150SLAM, SLAMF1, IPO-3T-cells (upregulated on activation), regulatory T-cells, B-cells, dendritic cells and endothelial cells.Costimulation of T-cells and B-cells.
CD151GP27, SFA-1, PETA-3Platelets, megakaryocytes, endothelial cells and epithelial cells.Essential for proper assembly of the glomerular and tubular basement membranes in kidney.
CD152CTLA-4Activated T-cells and activated B-cells.Negative regulation of T-cell activation. Contributes to the maintenance of peripheral T-cell tolerance to self antigens. It exerts its major effects on T-cell immune responses via regulation of the cell cycle.
CD153CD30 ligandActivated T-cells, activated macrophages, neutrophils and B-cells.Binds to CD30 and induces proliferation of T-cells.
CD154CD40 ligand, Gp39, TRAPActivated CD4+ T-cells.Mediates B-cell proliferation and IgE production in the presence of IL4. Also involved in antibody class switching, modulation of apoptosis in the germinal center through interaction with B-cells expressing CD40 and activation of CD4+ T-cells.
CD155Poliovirus Receptor, NECL-5Monocytes, macrophages, thymocytes and CNS neurons.Mediates natural killer cell adhesion and triggers their effector functions. Plays a role in mediating tumor cell invasion and migration, receptor for polio virus attachment.
CD156aADAM8Monocytes and neutrophils.Possible involvement in extravasation of leukocytes.
CD156bADAM17, TACEUbiquitously expressed.Cleaves transmembrane form of TNF-α to generate the soluble active form.
CD156cADAM10, CDw156Spleen, lymph nodes, thymus, peripheral blood leukocytes, bone marrow, chondrocytes and fetal liver.Metalloprotease activity, cell-cell and cell-matrix interaction, responsible for the proteolytic release of several cell-surface proteins such as the HER2 receptor.
CD157BST-1Monocytes, neutrophils and endothelial cells.Synthesis of cyclic ADP-ribose and putative involvement in pre-B-cell growth.
CD158aNKAT-1Natural killer cells and T-cell subsets.Receptor on natural killer cells for HLA-C alleles. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158b1NKAT-6Natural killer cells and T-cell subsets.Receptor on natural killer cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158b2NKAT-2Natural killer cells and T-cell subsets.Receptor on natural killer cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158cKIR3DP1Natural killer cells.Secreted to the extracellular medium and involved in the suppression of natural killer cell-mediated cytotoxicity.
CD158dKIR2DL4, KIR-103ASNatural killer cells.Receptor on natural killer cells for HLA-C alleles. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158eNKAT-3, KIR3DL1Natural killer cells.Receptor on natural killer cells for HLA Bw4 allele. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158f1KIR2DL5ANatural killer cells.Receptor on natural killer cells for HLA-C alleles. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158f2KIR2DL5BNatural killer cells.Receptor on natural killer cells for HLA-C alleles. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158gNKAT-9, KIR2DS5Natural killer cells.Receptor on natural killer cells for HLA-C alleles. Does not inhibit the activity of natural killer cells.
CD158hKIR2DS1Natural killer cells.Receptor on natural killer cells for HLA-C alleles. Does not inhibit the activity of natural killer cells.
CD158iNKAT-8, KIR2DS4Natural killer cells.Receptor on natural killer cells for HLA-C alleles. Does not inhibit the activity of natural killer cells.
CD158jNKAT-5, KIR2DS2Natural killer cells.Receptor on natural killer cells for HLA-C alleles. Does not inhibit the activity of natural killer cells.
CD158kNKAT-4, KIRDL2Natural killer cells.Receptor on natural killer cells for HLA-A alleles. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158zKIR3DL3Natural killer cells.Receptor on natural killer cells. May inhibit the activity of natural killer cells thus preventing cell lysis.
CD159aNKG2A, KLRC1Natural killer cells and γδ T-cells.Negative regulation of natural killer cell activation. Implicated in the recognition of the MHC class I HLA-E molecules by natural killer cells and some cytotoxic T-cells.
CD159cNKG2C, KLRC2Natural killer cells and CD8+ T-cells.Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by natural killer cells and some cytotoxic T-cells.
CD160BY55Peripheral blood natural killer cells and CD8+ T-cells with cytolytic effector activity.Receptor showing broad specificity for both classical and non-classical MHC class I molecules.
CD161NKR-P1A, KLRB1Intestinal epithelium and liver natural killer cells and peripheral blood T-cells.Inhibits natural killer cell mediated cytotoxicity. Induces immature thymocyte proliferation.
CD162PSGL-1Monocytes, granulocytes, most T- and B-cells and stem cells.Binds E-, P- and L-selectins and mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.
CD163M130Monocytes and macrophages.Clearance and endocytosis of hemoglobin / haptoglobin complexes by macrophages.
CD163bCD163L1, M160Isoform 1: monocytes and macrophages. Isoform 2: spleen.Clearance and endocytosis of hemoglobin / haptoglobin complexes by macrophages.
CD164MUC-24, MGC-24Isoform 1: prostate cancer tumors and osseous metastases. Isoform 2: Small and large bowel as well as lung and thyroid epithelia. Isoform 4: Hematopoietic progenitor cells and bone marrow stromal cells.May play a role in hematopoiesis. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis, positively regulates myoblast migration and promotes myoblast fusion into myotubes.
CD165AD2, gp37Lymphocyte subsets, monocytes, immature thymocytes, platelets and epithelial cells.Important for adhesion of thymocytes to thymic epithelial cells.
CD166ALCAMActivated T- and B-cells, monocytes, thymic epithelial cells and neurons.Mediates cell adhesion by binding to CD6. Involved in neurite extension and may play a role in the binding of T- and B-cells to activated leukocytes.
CD167aDDR1Highest expression in the brain, lung, placenta and kidney.Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation.
CD167bDDR2Osteocytes, osteoblastic cells and bone lining cells. Also expressed in heart and lung.Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development.
CD168HMMRMonocytes and T-cell subsets.Hyaluronan receptor. CD168 activation by Hyaluronan regulates cell migration, proliferation, signaling, regulation of gene expression, cell differentiation, morphogenesis and metastasis, Involved in cellular transformation and metastasis formation.
CD169Sialoadhesin, Siglec-1Macrophages.Endocytic receptor mediating clathrin-dependent endocytosis.
CD170SIGLEC5, OB-BP2Macrophages, neutrophils and dendritic cells.Adhesion molecule mediating sialic-acid dependent binding to cells.
CD171NCAM-L1, L1CAMT- and B-cell subsets, monocytes and neurons.Adhesion molecule involved in axon growth, fasciculation, neural migration and neuronal differentiation.
CD172aSHPS-1, SIRPAMonocytes, granulocytes, dendritic cells, brain and stem cells.Immunoglobulin-like cell surface receptor for CD47. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
CD172bSIRPB1Monocytes and dendritic cells.Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.
CD172gSIRPG, SIRPB2CD4+ and CD8+ T-cells and activated NK cells.Immunoglobulin-like cell surface receptor that mediates cell-cell adhesion on binding with CD47.
CD173Blood group H type 2Erythrocytes, stem cell subsets and platelets.Precursor to the A- and B-blood group antigens.
CD174Lewis YStem cell subsets, erythrocytes and epithelial cells.May be involved in the homing process of hematopoietic stem cells to the bone marrow.
CD175TnStem cell subsets and epithelial cells.Histo-blood group related carbohydrate antigen.
CD175sSialyl TnErythroblasts, endothelial cells and epithelial cells.Binds CD22, Siglec-3-5 and 6. Implicated in the induction of metastasis and invasiveness of tumors. Overexpressed in several carcinomas and is associated with poor prognosis.
CD176Thomsen-Friedenreich antigenStem cell subsets and epithelial cells.Acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy.
CD177NB1 glycoprotein, HNA-2aNeutrophils.Major immunogenic molecule of neutrophil membrane.
CD178Fas ligand, CD95 ligandActivated T-cells, dendritic cells, tumor cells and testes.T-cell mediated cytotoxicity. Induces apoptosis in Fas-expressing target cells.
CD179aVpreB1Pre-B-cells.Early B-cell differentiation.
CD179bλ5Pre-B-cells.B-cell development.
CD180RP105Mature peripheral B-cells, monocytes and dendritic cells.Mediates the innate immune response to bacterial LPS in B-cells. Leads to NFkB activation. Also involved in the life / death decision of B-cells.
CD181CXCR1, IL8R alphaNeutrophils, basophils, natural killer cells, T-cell subset, monocytes and endothelial cells.Neutrophil chemotaxis and activation.
CD182CXCR2Neutrophils, basophils, natural killer cells, T-cell subset, monocytes and endothelial cells.Neutrophil chemotaxis and activation.
CD183CXCR3T-cell subsets, B-cells, natural killer cells, monocytes, macrophages and proliferating endothelial cells.T-cell chemotaxis, integrin activation, cytoskeletal changes and chemotactic migration in inflammation-associated effector T-cells.
CD184CXCR4T-cell subsets, B-cells, dendritic cells, monocytes and endothelial cells.Cell migration, hematopoietic progenitor cell homing and HIV-1 cell entry.
CD185CXCR5Mature B-cells and Burkitt lymphoma cells.Binds B-cell chemoattractant BL. Involved in B-cell migration into B-cell follicles of spleen and Peyer patches.
CD186CXCR6, BonzoTh1 cells, B-cell subsets and natural killer cell subsets.Receptor for CXCL16. Involved in T-cell recruitment and is an HIV-1 co-receptor.
CD191CCR1Monocytes, macrophages, lymphocytes, dendritic cells and hematopoietic stem cells.Binds to MIP-1-alpha, MIP-1-delta, RANTES and MCP-3. Involved in leukocyte chemotaxis and affecting stem cell proliferation.
CD192CCR2Monocytes, B-cells, activated T-cells and dendritic cells.Leukocyte chemotaxis and is an HIV co-receptor.
CD193CCR3Eosinophils, trace amounts in neutrophils and monocytes.Leukocyte chemotaxis and is an HIV co-receptor.
CD194CCR4CD4+ T-cells, basophils, platelets, macrophages and natural killer cells.Chemoattractant homing receptor on circulating memory lymphocytes. Co-receptor for some primary HIV-2 isolates.
CD195CCR5Monocytes and T-cell subsets.Leukocyte chemotaxis and is an HIV co-receptor.
CD196CCR6, CKR-L3, GPRCY4Lymphocytes and dendritic cells.Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and affects dendritic cell chemotaxis.
CD197CCR7, BLR2Activated T- and B-cells. Strongly upregulated in B-cells infected with Epstein-Barr.Receptor for MIP-3-beta. Mediator of Epstein-Barr virus effects on B-cells and lymphocyte migration into lymph nodes.
CDw198CCR8, CKR-L1, GPRCY6Monocytes, T-cell subsets, dendritic cells and HUVEC cells.Regulates monocyte chemotaxis and thymic cell line apoptosis, is a co-receptor for HIV-1 infection.
CDw199CCR9Thymocytes, lymphocytes and melanoma cells.Regulates chemotaxis, is a co-receptor for HIV-1 infection.
CD200OX-2Thymocytes, B-cells, activated T-cells, endothelial cells and keratinocyte subsets.Down-regulatory signal for myeloid cell function, costimulates T-cell proliferation.
CD201EPCREndothelial cell subsets.Enhances protein C activation, involved in the protein C pathway controlling blood coagulation.
CD202bTIE2, TEKEndothelial cells and angioblasts.Regulates angiogenesis, endothelial cell survival, proliferation, migration and adhesion.
CD203aENPP1, M6S1, NPPS, PC1, PDNP1Plasma cells and some non-lymphoid tissues.ATP hydrolysis at the plasma membrane. May also modulate insulin sensitivity
CD203cENPP3Basophils, mast cells and their progenitors.Enzyme catalyzing hydrolysis of deoxynucleotides, nucleotide sugars and NAD.
CD204MSR1Monocyte-derived macrophages.Endocytosis of macromolecules including low density lipoproteins, host defense.
CD205DEC205Dendritic cells, B-cells and thymic epithelial cells.Endocytic receptor enhancing antigen presentation, causes reduced proliferation of B-cells.
CD206MMRMacrophages, monocytes and Langerhans cells.Endocytosis (phagocytosis and pinocytosis) of mannose-containing solutes.
CD207LangerinLangerhans cells.Facilitates uptake of antigens and is involved in the routing and / or processing of antigen for presentation to T-cells.
CD208LAMP3Dendritic cells.Dendritic cell maturation marker, involved in cell proliferation.
CD209DC-SIGNDendritic cells, placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells and THP-1 monocytes.Mediates antigen endocytosis and degradation binds pathogenic antigens such as HIV1 gp120.
CD210IL10RA, IL10R1, CDw210aMonocytes, B- and T-cells and large granular lymphocytes.Receptor for IL10, inhibits macrophage activation by interferon-gamma.
CDw210bIL10RB, IL10R2Monocytes, macrophages, dendritic cells, B- and T-cells.Forms part of the receptor complexes for IL10, IL22, IL26, IL28, and IL29.
CD212IL12RB1Activated T-cells and natural killer cells.Forms part of the receptor complexes for IL12 and IL23.
CD213a1IL13RA1B- and T-cells, monocytes and endothelial cells.Forms part of the receptor complexes for IL13 and IL4.

CD213a2
IL13RA2B-cells and monocytes.Forms part of the receptor complex for IL13.
CD215IL15RAWidely expressed.Receptor for IL15.
CD217IL17RB- and T-cells, monocytes, macrophages and granulocytes.Receptor for IL17A and IL17F.
CD218aIL18R1B- and T-cell subsets, natural killer cells, monocytes, granulocytes and endothelial cells.Forms part of the receptor complex for IL18.
CD218bIL18Rbeta, IL18RAPNatural killer cells, T-cell subsets, monocytes and endothelial cells.Forms part of the receptor complex for IL18.
CD220Insulin receptorWidely expressed in tissue targets of insulin metabolic effects.Tyrosine-protein kinase activity. Binding of insulin stimulates its association with downstream mediators including insulin receptor substrates and phosphatidylinositol 3'-kinase (PI3K), which leads to glucose uptake.
CD221Insulin-like growth factor 1 receptorWide tissue expression.Mediates insulin-stimulated DNA synthesis and insulin-like growth factor 1-stimulated cell proliferation and differentiation.
CD222M6PR, IGFII-RLymphocytes, monocytes, granulocytes and fibroblasts.Transports phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes.
CD223LAG-3Activated natural killer and T-cells.Involved in lymphocyte activation, negative regulation of T-cell activation.
CD224GGT1T- and B-cells, monocytes, macrophages and stem cells.Catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors, which contributes to oxidative homeostasis.
CD225IFITM1, Leu-13, DSPA2aT- and B-cells, monocytes, endothelial cells, osteocytes and osteoblasts.Inhibits viral entry, implicated in cell adhesion, control of cell growth and migration. Relays antiproliferative and homotypic adhesion signals.
CD226DNAM-1, PTA1T-cells, natural killer cells, monocytes and platelets.Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and natural killer cells.
CD227MUC1, PUM, EMAT-cells, monocytes, macrophages, epithelial cells and stem cell subsets.Cell adhesion and signaling  through phosphorylations and protein-protein interactions.
CD228Melanotransferrin, MFI2Endothelial cells, stem cells and melanoma cells.Involved in cellular iron uptake.
CD229Ly9T- and B-cells.Involved in adhesion between T-cells and accessory cells.
CD230PrPBroad antigenic expression.Involved in neuronal development and synaptic plasticity. Altered forms of the protein are responsible for prion diseases.
CD231Tspan-7, TALLA-1T-cells and endothelial cells.Potentially involved in cell proliferation and motility.
CD232Plexin-C1, VESP-RMelanocytes, monocytes, B-cells and natural killer cells.Receptor for SEMA7A, smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Potential anti-tumor role in melanomas.
CD233Band 3, AE1Erythrocytes.Anion exchanger across the cytoplasmic membrane, binding site for cytoskeletal proteins, enzymes and hemoglobin.
CD234Duffy antigen receptor, DARCErythrocytes, endothelial cells and epithelial cells.Receptor for Plasmodium spp. Non-specific chemokine receptor.
CD235aGlycophorin-AErythrocytes.Major erythrocyte intrinsic membrane protein. Minimizes erythrocyte aggregation, receptor for influenza virus, Plasmodium falciparum and Hepatitis A virus.
CD235bGlycophorin-BErythrocytes.Minor sialoglycoprotein in erythrocyte membranes, receptor for Plasmodium falciparum.
CD236Glycophorin-C/DTwo isoforms produced by alternative splicing: Glucophorin-C is expressed in erythrocytes, Glycophorin-D is ubiquitously expressed.Glycophorin-C regulates the stability of red cells.
CD238Kell blood group glycoproteinErythrocytes, Sertoli cells and follicular dendritic cells.Zinc endopeptidase cleaving endothelin 3 .
CD239Lutheran blood group antigen, B-CAMErythrocytes, endothelial cells and epithelial cells.Laminin alpha-5 receptor, plays a role in erythrocyte differentiation and trafficking.
CD240CEBlood group Rh(CE) polypeptideErythrocytes.Part of an oligomeric complex with a putative transport or channel function in the erythrocyte membrane.
CD240DBlood group Rh(D) polypeptideErythrocytes.Part of an oligomeric complex with a putative transport or channel function in the erythrocyte membrane.
CD241RHAG, RH50Erythrocytes.Ammonium transporter, associated with rhesus blood group antigen expression.
CD242ICAM-4Erythrocytes.Ligand for the leukocyte adhesion protein LFA-1, critical in erythroblastic island formation.
CD243MDR-1Stem cells and drug resistant tumor cells.TP binding cassette transport protein. Influences uptake, tissue distribution and elimination of P-glycoprotein transported toxins and drugs.
CD2442B4, NAILnatural killer cells, basophils and monocytes.Natural killer cell activation, natural killer cell and T-cell interaction.
CD245p220/240T-cell subsets.Signal transduction and co-stimulation of T- and natural killer cells.
CD246ALKEmbryonic neurons of CNS and PNS.Tyrosine kinase receptor for pleiotrophin and midkine. Induces cell proliferation and differentiation in the nervous system.
CD247TCR Z chainT-cells and natural killer cells.Plays a role in the assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
CD248EndosialinTumor endothelial cells and stromal fibroblasts.Plays a role in tumor angiogenesis.
CD249EAP, Aminopeptidase AEpithelial cells and endothelial cells.Converts angiotensin II to angiotensin III.

CD252
OX40LDendritic cells, activated B-cells, endothelial cells and mast cells.Ligand for receptor TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
CD253Apo-2L, TRAILActivated T-cells and natural killer cells.Initiates apoptosis of tumor cells by binding to either DR4 or DR5 receptors.
CD254ODF, OPGK, RANKL, TRANCEActivated T-cells, stromal cells and osteoclasts.Plays a role in T- and B-cell as well as T-cell and dendritic cell interactions. Involved in osteoclast differentiation and consequently bone resorption.
CD256APRIL, TALL-2, TRDL-1Leukocytes, pancreatic cells and colon.T- and B-cell proliferation, activates NFkB, and induces cell death. May be involved in monocyte / macrophage-mediated immunological processes.
CD257BAFF, TALL-1Monocytes, macrophages, T-cells and dendritic cells.Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
CD258TNFRSF14, HVEM-LActivated T-cells, activated monocytes and B-cells.Stimulates T-cell proliferation, receptor for Herpes simplex virus.
CD261DR4, TRAIL-R1Activated T-cells and selected tumor cells.Induces apoptosis, promotes activation of NFkB.
CD262DR5, TRAIL-R2Leukocytes and selected tumor cells.Activated by TNFSF10 / TRAIL and transduces apoptosis signal.
CD263DcR1, TRAIL-R3Low expression in most cells and negative in most tumor cells.Receptor for TRAIL, competes with TRAIL-R1 and TRAIL-R2 thus inhibiting apoptosis.
CD264DCR2, TRAIL-R4Low expression in most cells and negative in most tumor cells.Receptor for TRAIL, inhibits apoptosis.
CD265RANK, ODFRDendritic cells and activated monocytes.Receptor for TRANCE, essential for osteoclastogenesis. Enhances T-cell growth and dendritic cell function, plays a role in lymph node organogenesis.
CD266TWEAKREndothelial cells.Receptor for TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
CD267TACIResting B-cells and activated T-cells.Receptor for CD256 and CD257, mediates activation of the transcription factors NFAT, AP1, and NFkB. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
CD268BAFF receptorResting B-cells, lower levels in activated B-cells and resting CD4+ cells.B-cell receptor for CD257. Promotes the survival of mature B-cells and B-cell response.
CD269BCMAMature B-cells.Receptor for CD256 and CD257, activates NFkB and JNK. Promotes B-cell survival and plays a role in the regulation of humoral immunity.
CD270HveA, TR2Widely expressed  .Receptor for CD258 and CD272. Plays an important role in Herpes simplex virus (HSV) pathogenesis and mediates HSV entry into activated human T-cells.
CD271NGF receptor, p75NTRSchwann cells, neurons, bone marrow-derived mesenchymal stem cells.Regulates  neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system.
CD272BTLACD4+ and CD8+ T-cells, remains expressed on Th1 cells but not Th2 cells.Lymphocyte inhibitory receptor, regulates lymphocyte activation and / or homeostasis as well as T-cell tolerance.
CD273PD-L2, B7-DCDendritic cells and activated monocytes.Stimulatory on dendritic cells,  inhibits T-cell activation upon engaging the PD1 receptor.  Mediates T-cell activation through non PD1 mediated interactions.
CD274PD-L1, B7-H1Activated T- and B-cells, dendritic cells, keratinocytes and monocytes.Essential for T-cell proliferation and production of interferon gamma and IL10. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
CD275B7-H2, B7RP-1Activated monocytes, macrophages and dendritic cells.Ligand for CD278. Costimulatory signal for T-cell proliferation and cytokine secretion, induces B-cell proliferation and differentiation.
CD276B7-H3Monocyte-derived dendritic cells, activated macrophages, epithelial cells, activated T-, B- and natural killer cells.Enhances the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. Regulatory role in bone formation.
CD277BTN3A1T- and B-cells, natural killer cells, monocytes, dendritic cells and endothelial cells.T-cell activation.
CD278ICOSActivated T-cells.Enhances all basic T-cell responses to foreign antigens including proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interactions, and effective help for antibody secretion by B-cells.
CD279PD-1Activated T- and B-cells.Inhibitory cell surface receptor involved in T-cell tolerance.
CD280MRC2Endothelial cells, fibroblasts and macrophages.Endocytotic lectin receptor displaying calcium-dependent lectin activity. Involved in cellular uptake, remodeling and lysosomal degradation of extracellular collagen matrices. May play a role in the plasminogen activation system controlling the extracellular level of PLAUR / PLAU.
CD281TRL1Monocytes, macrophages, dendritic cells and keratinocytes.Pathogen recognition and activation of innate immunity, regulates TLR2 function.
CD282TLR2Monocytes, granulocytes, macrophages, dendritic cells, keratinocytes and epithelial cells.Mediator of innate immunity against bacterial cell wall lipoproteins. Induces activation of NFkB.
CD283TLR3Dendritic cells, fibroblasts, epithelial cells, glial cells and neurons.Mediator of innate immunity against viral infection, activated by dsDNA.
CD284TLR4Monocytes, macrophages, dendritic cells and T-cell subsets.Mediator to innate immunity against bacterial polysaccharides. Induces activation of NFkB and production of type I interferons.
CD286TLR6Monocytes, CD11c+ dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.TLR6:TLR2 dimers coordinate macrophage activation by Gram positive bacteria and fungal zymosan. Initiates proinflammatory cascades and apoptotic responses, acts via MYD88 and TRAF6, leading to NFkB activation, cytokine secretion and the inflammatory response.
CD288TLR8Monocytes, macrophages, dendritic cells and neurons.Role in pathogen recognition and activation of innate immunity. Activated by viral ssRNA and bacterial RNA.
CD289TLR9Peripheral blood leukocytes and plasmacytoid pre-dendritic cells.Participates in the innate immune response to microbial agents. Activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides, it acts via MYD88 and TRAF6, leading to NFkB activation, cytokine secretion and the inflammatory response.
CD290TLR10B-cells and dendritic cells .Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B- activation, cytokine secretion and the inflammatory response.
CD292BMPR-1A, ALK-3, SKR5Skeletal muscle cells, bone progenitor cells, chondrocytes and mesenchymal cells.Receptor for BMP-2 and BMP-4. Plays a role in apoptosis and adipocyte development, cell differentiation and extracellular matrix deposition by osteoblasts.
CDw293BMPR-1BMesenchymal cells, bone progenitor cells, chondrocytes and epithelial cells.Receptor for BMP7 and GDF5. Plays a role in chodrogenesis.
CD294GPR44Th2 cells, basophils and eosinophils.Regulates immune and inflammatory responses, induces Th2 cell, eosinophil and basophil migration.
CD295LEP-R, OB-RHematopoieic cells, heart, liver, kidney and pancreatic cells.Receptor for leptin. Involved in the regulation of fat metabolism and required for normal lymphopoiesis.
CD296ART1Neutrophils, cardiac and skeletal muscle cells.Catalyzes the transfer of ADP-ribose from NAD+ to arginine residues in proteins.
CD297ART4Erythrocytes, monocytes, macrophages, basophils and endothelial cells.Plays a role in the metabolism of Dombrock blood group antigen.
CD298ATP1B3Neuronal cells.Component of Na+-K+ pump on neuronal membranes.
CD299CLEC4M, L-SIGN, DC-SIGNRLiver and lymph node endothelial cells.Pathogen-recognition receptor involved in peripheral immune surveillance in liver. Recognizes mannose N-linked oligosaccharides in HIV-1, HIV-2, human cytomegalovirus and human SARS coronavirus.
CD300aCLM-8Natural killer cells, T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer cells, and to the down-regulation of mast cell degranulation.
CD300bCLM-7, IREM3Basophils, mast cells, eosinophils, neutrophils, monocytes and macrophages.Activating immune receptor by interaction with TYROBP.
CD300cCLM-6Monocytes, neutrophils, peripheral blood T- and B-cells.Regulates IFN-alpha and TNF-alpha secretion by plasmacytoid dendritic cells.
CD300dCLM-4Basophils, mast cells, eosinophils, neutrophils, monocytes and macrophages.Regulation of the expression of other CD300 molecules
CD300eCLM-2, IREM-2Monocytes, macrophages and myeloid dendritic cells.Prevents apoptosis, triggers the production of pro-inflammatory cytokines and upregulates the expression of cell surface co-stimulatory molecules.
CD300fCLM-1, IREM-1Monocytes, macrophages and mast cells.Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation.
CD300gCLM-9, TREM4Endothelium.May mediate L-selectin-dependent lymphocyte rollings
CD301CLEC10AMacrophages and immature dendritic cells.Plays a role in cell adhesion, cell-cell signaling and cellular recognition through glycoprotein binding.
CD302
Monocytes, macrophages and dendritic cells.Functions in endocytosis and phagocytosis as well as in cell adhesion and migration.
CD303CLEC4C, BCDA-2Plasmacytoid dendritic cells and immature monocyte-derived dendritic cells.Antigen-capturing and peptide loading into compartments for presentation to T-cells. May mediate inhibition of induction of IFN-alpha / beta expression in plasmacytoid dendritic cells. May act as signaling receptor activating protein-tyrosine kinases and mobilizing intracellular calcium.
CD304Neuropilin 1Dendritic cells, T-cells, neurons and endothelial cells.Regulates VEGF-induced angiogenesis, dendritic cell and T-cell interaction, as well as neuritogenesis.
CD305LAIR1T- and B-cells, natural killer cells, dendritic cells, monocytes and macrophages.Inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer cells, B- and T-cells.
CD306LAIR2Monocytes and T-cells.Inhibits cellular activation and inflammation.
CD307aFcRL1Mature B-cell subsets.May function in B-cells activation and differentiation.
CD307bFcRL2Mature B-cell subsets.Regulatory role in normal and neoplastic B cell development.
CD307cFcRL3Mature B-cell subsets.Interacts with PTPN6, PTPN11, SYK and ZAP-70.
CD307dFcRL4, IRTA1Memory and monocytoid B-cells.Putative inhibitor of B-cell receptor signaling.
CD307eFcRL5Mature and memory B-cells.May be involved in B-cell development and differentiation.
CD309VEGFR-2Endothelial cells and primitive stem cells.Activation of this receptor by VEGF plays a role in angiogenesis, development, wound healing, cell proliferation, migration and differentiation.
CD312EMR2Macrophages, activated monocytes, dendritic cells, granulocytes, hepatocytes and lung cells.Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.
CD314NKG2D, KLRK1Natural killer cells, T-cell subsets and dendritic cell subsets.Receptor for the recognition of MHC class I HLA-E molecules by natural killer cells and some cytotoxic T-cells.
CD315PTGFRNMegakaryocytes, hepatocytes, epithelial cells and endothelial cells.Inhibits binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor.
CD316IGSF8, EWI-2, KCT-4B-cells, T-cells and natural killer cells.Negative regulator of cell motility. May regulate neurite outgrowth and maintenance of the neural network in the brain.
CD317BST2T-cells, monocytes, natural killer cells and dendritic cells.IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells.
CD318CDCP1, SIMA135Hematopoietic stem cells and epithelial cells.May be involved in cell adhesion and cell matrix association. Potential role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. Possible marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
CD319SLAMF7, CRACCNatural killer cells and activated B-cells.Mediates natural killer cell activation and may play a role in lymphocyte adhesion.
CD320FDC-SM-8D6, TCbIRFollicular dendritic cells.Augments the proliferation of plasma cell precursors generated by IL10. Receptor for the cellular uptake of transcobalamin bound cobalamin.
CD321JAM-A, JAM-1, PAM-1, F11REpithelial cells, endothelial cells, leukocytes, platelets and erythrocytes.Plays a role in epithelial tight junction formation, regulation of leukocyte migration, epithelial barrier maintenance and platelet activation.
CD322JAM-B, JAM-2, VE-JAMHigh endothelial cells.May play a role in lymphocyte homing to secondary lymphoid organs.
CD324E-Cadherin, CDH1Epithelial cells, keratinocytes, trophoblasts and platelets.Calcium-dependent cell adhesion protein. Involved in cell-cell and cell-matrix adhesion, tumor suppression, cell growth and differentiation.
CD325N-Cadherin, Cadherin-2, CDH2Neurons, striated and cardiac muscle cells, fibroblasts, epithelial cells, pancreatic cells and hepatocytes.May be involved in neuronal recognition mechanisms. In hippocampal neurons, may regulate dendritic spine density.
CD326Ep-CAM, EGP314Embryonic stem cells, epithelial cells and adenocarcinomas.May act as a physical homophilic interaction molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosal epithelium for providing an immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation.
CD327Siglec-6, OB-BP1B-cells, placenta trophoblastic cells and granulocytes.Adhesion molecule that mediates sialic-acid dependent binding to cells.
CD328Siglec-7, AIRM-1Natural killer cells, monocytes and granulocytes.Adhesion molecule that mediates sialic-acid dependent binding to cells. Mediates inhibition of natural killer cell cytotoxicity. May play a role in hematopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
CD329Siglec-8, SAF-2Eosinophils.Adhesion molecule that mediates sialic-acid dependent binding to cells.
CD331FGFR1, BFGFR, FLT-2Epithelial cells, endothelial cells, fibroblasts, mesenchymal cells and cardiomyocytes. Also expressed in astrocytoma, neuroblastoma and adrenal cortex cell lines.Cell-surface receptor for fibroblast growth factors. Plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration.
CD332FGFR2, KGFRNeurons, hepatocytes, fibroblasts and epithelial cells.Cell-surface receptor for fibroblast growth factors. Plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development.
CD333FGFR3Brain, kidney, adult testes.Cell-surface receptor for fibroblast growth factors. Plays an essential role in the regulation of cell proliferation, differentiation and apoptosis, as well as in chondrocyte differentiation, proliferation and apoptosis. Required for normal skeleton development.
CD334FGFR4Liver, kidney, lung, pancreatic cells, lymphocytes and macrophages.Cell-surface receptor for fibroblast growth factors. Plays a role in the regulation of cell proliferation, differentiation and migration, as well as in the regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis.
CD335NCR1, NK-p46Natural killer cells.Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer cells to mediate tumor cell lysis.
CD336NCR2, NK-p44Activated natural killer cells.Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer cells to mediate tumor cell lysis.
CD337NCR3, NK-p30Natural killer cells.Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer cells to mediate tumor cell lysis.
CD338ABCG2Hepatocytes, intestinal epithelial cells, kidney, lung and placental cells.Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux.
CD339Jagged1, JAG1Bone marrow stromal cells, thymic epithelium, endothelial cells, Schwann cells, keratinocytes, ovarian, prostate, pancreatic, placenta and heart cells.Ligand for multiple Notch receptors. Involved in the mediation of Notch signaling, cell fate determination in hematopoiesis and cardiovascular development.
CD340ERBB2, MLN 19Epithelial and endothelial cells, keratinocytes, hematopoietic stem cell subsets, fetal mesodermal cells and extraembryonic tissues.Protein tyrosine kinase forming part of several cell surface receptor complexes. Essential component of a neuregulin-receptor complex, regulates outgrowth and stabilization of peripheral microtubules.
CD344Frizzled-4, Fz-4, FzE4Ubiquitous expression. Highest expression in adult cardiac cells, striated muscle cells, ovary and fetal kidney.Receptor for Wnt proteins, may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis. Plays a critical role in retinal angiogenesis.
CD349Frizzled-9, Fz-9, FZD9Mesenchymal stem cells, neural precursors, mammary epithelial cells, neurons, testes and kidney.Receptor for Wnt proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and / or in differentiated tissues.
CD350Frizzled-10, Fz-10, FZD10Placenta, fetal kidney, fetal lung and fetal brain.Receptor for Wnt proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and / or in differentiated tissues.
CD351FCAMRMesangial cells.Receptor for the Fc fragment of IgA and IgM. May function in the immune response to microbes mediated by IgA and IgM.
CD352NTB-A, SLAMF6Natural killer cells, T- and B-cells.Triggers cytolytic activity only in natural killer cells expressing high surface densities of natural cytotoxicity receptors.
CD353SLAMF8Thymocytes, splenocytes and bone marrow cells.May play a role in B-lineage commitment and / or modulation of signaling through the B-cell receptor.
CD354TREM-1Hepatocytes, lung cells, splenocytes and peripheral blood leukocytes.Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Acts as an amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
CD355CRTAMT-cell subsets, splenocytes, thymocytes, peripheral blood leukocytes and Purkinje cells.Interaction with CADM1 promotes natural killer cell cytotoxicity and IFN-gamma secretion by CD8+ cells in vitro as well as natural killer cell-mediated rejection of tumors expressing CADM3 in vivo.
CD357TNFRSF18Lymphocytes and peripheral blood leukocytes.Receptor for TNFSF18. Seems to be involved in interactions between activated T-cells and endothelial cells and in the regulation of T-cell receptor-mediated cell death.
CD358TNFRSF21Cardiomyocytes, neurons, placental cells, pancreatic cells and lymphocytes.May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning.
CD360IL-21RLymphoid tissues, particularly thymus and spleen.Receptor for interleukin-21.
CD361EVI2BB-cells, bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines.Possibly involved in melanocyte and keratinocyte differentiation
CD362Syndecan-2, HSPG, SDC2T-cells.Cell surface proteoglycan that bears heparan sulfate.
CD363S1PR1Endothelial cells, vascular smooth muscle cells, fibroblasts and melanocytes.Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells.


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