RabMAb

Anti-Presenilin 2 (phospho S327)抗体[EP2613Y] (ab76114)

概述

  • 产品名称Anti-Presenilin 2 (phospho S327)抗体[EP2613Y]
    参阅全部 Presenilin 2 一抗
  • 描述
    兔单克隆抗体[EP2613Y] to Presenilin 2 (phospho S327)
  • 特异性ab76114 detects Presenilin 2 phosphorylated on serine 327.
  • 经测试应用适用于: WB, IPmore details
    不适用于: Flow Cyt,ICC or IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A phospho specific peptide corresponding to residues surrounding serine 327 of human Presenilin 2

  • 阳性对照
    • Hela cell lysates.
  • 常规说明

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

应用

Our Abpromise guarantee covers the use of ab76114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/5000. Detects a band of approximately 23 kDa (predicted molecular weight: 50 kDa).
IP 1/10.
  • 应用说明Is unsuitable for Flow Cyt,ICC or IHC-P.
  • 靶标

    • 功能Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
    • 组织特异性Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
    • 疾病相关Defects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889]. AD is an autosomal dominant Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
      Defects in PSEN2 are the cause of cardiomyopathy dilated type 1V (CMD1V) [MIM:613697]. It is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    • 序列相似性Belongs to the peptidase A22A family.
    • 结构域The PAL motif is required for normal active site conformation.
    • 翻译后修饰Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.
      Phosphorylated on serine residues.
    • 细胞定位Endoplasmic reticulum membrane. Golgi apparatus membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AD3L antibody
      • AD3LP antibody
      • AD4 antibody
      • AD5 antibody
      • Alzheimer disease 4 antibody
      • CMD1V antibody
      • E5-1 antibody
      • OTTHUMP00000035671 antibody
      • OTTHUMP00000035672 antibody
      • OTTHUMP00000228286 antibody
      • OTTHUMP00000228288 antibody
      • Presenilin 2 (Alzheimer disease 4) antibody
      • Presenilin 2 antibody
      • Presenilin-2 CTF subunit antibody
      • PS-2 antibody
      • PS2 antibody
      • Psen2 antibody
      • PSN2_HUMAN antibody
      • PSNL2 antibody
      • STM-2 antibody
      • STM2 antibody
      see all

    Anti-Presenilin 2 (phospho S327) antibody [EP2613Y] 图像

    • All lanes : Anti-Presenilin 2 (phospho S327) antibody [EP2613Y] (ab76114) at 1/5000 dilution

      Lane 1 : HeLa cell lysates un-treated
      Lane 2 : HeLa cell lysates treated with AP

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 50 kDa
      Observed band size : 23 kDa (why is the actual band size different from the predicted?)

    Anti-Presenilin 2 (phospho S327) antibody [EP2613Y] (ab76114)参考文献

    ab76114 has not yet been referenced specifically in any publications.

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