Anti-Presenilin 2抗体[198C679.2.1] (ab13926)

概述

  • 产品名称Anti-Presenilin 2抗体[198C679.2.1]
    参阅全部 Presenilin 2 一抗
  • 描述
    小鼠单克隆抗体[198C679.2.1] to Presenilin 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (Human).

  • 阳性对照
    • HL-60 or Jurkat cells

性能

应用

Our Abpromise guarantee covers the use of ab13926 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: 1/250 - 1/500. Detects a band of approximately 55 kDa (predicted molecular weight: 54 kDa). It tested negative in mouse NIH 3T3 cells.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
    • 组织特异性Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
    • 疾病相关Defects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889]. AD is an autosomal dominant Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
      Defects in PSEN2 are the cause of cardiomyopathy dilated type 1V (CMD1V) [MIM:613697]. It is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    • 序列相似性Belongs to the peptidase A22A family.
    • 结构域The PAL motif is required for normal active site conformation.
    • 翻译后修饰Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.
      Phosphorylated on serine residues.
    • 细胞定位Endoplasmic reticulum membrane. Golgi apparatus membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AD3L antibody
      • AD3LP antibody
      • AD4 antibody
      • AD5 antibody
      • Alzheimer disease 4 antibody
      • CMD1V antibody
      • E5-1 antibody
      • OTTHUMP00000035671 antibody
      • OTTHUMP00000035672 antibody
      • OTTHUMP00000228286 antibody
      • OTTHUMP00000228288 antibody
      • Presenilin 2 (Alzheimer disease 4) antibody
      • Presenilin 2 antibody
      • Presenilin-2 CTF subunit antibody
      • PS-2 antibody
      • PS2 antibody
      • Psen2 antibody
      • PSN2_HUMAN antibody
      • PSNL2 antibody
      • STM-2 antibody
      • STM2 antibody
      see all

    Anti-Presenilin 2 antibody [198C679.2.1] 图像



    • Predicted band size : 54 kDa


      Western blot analysis for Presenilin 2 using ab13926 at 1/500 against 30 ug/lane of HL-60 cell lysate. A protein band of approximate molecular weight of 55 kDa was detected.

    Anti-Presenilin 2 antibody [198C679.2.1] (ab13926)参考文献

    ab13926 has not yet been referenced specifically in any publications.

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