Anti-Prealbumin抗体(ab106558)
Key features and details
- Chicken polyclonal to Prealbumin
- Suitable for: WB, IHC-P
- Reacts with: Human, Recombinant fragment
- Isotype: IgY
概述
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产品名称
Anti-Prealbumin抗体
参阅全部 Prealbumin 一抗 -
描述
鸡多克隆抗体to Prealbumin -
宿主
Chicken -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human, Recombinant fragment -
免疫原
Synthetic peptide corresponding to Human Prealbumin (internal sequence).
Database link: P02766 -
阳性对照
- WB: Recombinant Prealbumin protein. Human lung tissue lysate. IHC-P: Human lung tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgY -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106558于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 16 kDa.
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IHC-P |
Use a concentration of 2.5 - 20 µg/ml.
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说明 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 16 kDa. |
IHC-P
Use a concentration of 2.5 - 20 µg/ml. |
靶标
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功能
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. -
组织特异性
Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. -
疾病相关
Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:105210]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.
Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:145680]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.
Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:115430]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. -
序列相似性
Belongs to the transthyretin family. -
结构域
Each monomer has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. -
细胞定位
Secreted. Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 7276 Human
- Omim: 176300 Human
- SwissProt: P02766 Human
- Unigene: 427202 Human
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别名
- Amyloid polyneuropathy antibody
- Amyloidosis I antibody
- ATTR antibody
see all
图片
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Western Blot of recombinant Prealbumin protein (125 ng) labeling Prealbumin with Anti-Prealbumin antibody (ab106558) at 1µg/ml.
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Immunohistochemical analysis of Prealbumin in Human lung tissue, using ab106558 at 2.5 µg/ml.
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Lane 1 : Anti-Prealbumin antibody (ab106558) at 1 µg/ml
Lane 2 : Anti-Prealbumin antibody (ab106558) at 2 µg/ml
All lanes : Human lung tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 16 kDa -
Immunohistochemical analysis of human lung tissue labelling Prealbumin with ab106558 at 20 ug/mL.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab106558 被引用在 1 文献中.
- Moore GR et al. Complement and Humoral Adaptive Immunity in the Human Choroid Plexus: Roles for Stromal Concretions, Basement Membranes, and Epithelium. J Neuropathol Exp Neurol 75:415-28 (2016). PubMed: 26994633