概述

  • 产品名称Anti-PRDM6抗体
    参阅全部 PRDM6 一抗
  • 描述
    兔多克隆抗体to PRDM6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 43-72 of Human PRDM6 (NP_001129711.1).

  • 阳性对照
    • Jurkat cell line lysates.

性能

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应用

Our Abpromise guarantee covers the use of ab123317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 64 kDa.

靶标

  • 功能Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.
  • 序列相似性Contains 4 C2H2-type zinc fingers.
    Contains 1 SET domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Gm92 antibody
    • PFM3 antibody
    • PR domain containing 6 antibody
    • PR domain containing protein 6 antibody
    • PR domain zinc finger protein 6 antibody
    • PR domain-containing protein 6 antibody
    • Prdm6 antibody
    • PRDM6_HUMAN antibody
    • PRISM antibody
    • Putative histone-lysine N-methyltransferase PRDM6 antibody
    • RGD1559594 antibody
    see all

Anti-PRDM6 antibody 图像

  • Anti-PRDM6 antibody (ab123317) at 1/100 dilution + Jurkat cell line lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 64 kDa

Anti-PRDM6 antibody (ab123317)参考文献

ab123317 has not yet been referenced specifically in any publications.

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