Anti-PRDM1/Blimp1抗体(ab119401)
Key features and details
- Rabbit polyclonal to PRDM1/Blimp1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-PRDM1/Blimp1抗体
参阅全部 PRDM1/Blimp1 一抗 -
描述
兔多克隆抗体to PRDM1/Blimp1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide, corresponding to a sequence around amino acids 124-128 (
DTVPK
) of Human PRDM1/Blimp1 (NP_001189.2 ). -
阳性对照
- Jurkat an Raji cell extracts
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 48% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
(without Mg2+ and Ca2+) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab119401于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/1000. Detects a band of approximately 95-100 kDa (predicted molecular weight: 93 kDa).
|
说明 |
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WB
1/500 - 1/1000. Detects a band of approximately 95-100 kDa (predicted molecular weight: 93 kDa). |
靶标
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功能
Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). -
序列相似性
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Contains 4 C2H2-type zinc fingers.
Contains 1 SET domain. -
翻译后修饰
Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.
Ubiquitinated by the SCF(FBXO11) complex, leading to its degradation by the proteasome. -
细胞定位
Nucleus. Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 639 Human
- Entrez Gene: 12142 Mouse
- Entrez Gene: 309871 Rat
- Omim: 603423 Human
- SwissProt: O75626 Human
- SwissProt: Q60636 Mouse
- Unigene: 436023 Human
- Unigene: 4800 Mouse
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别名
- B Lymphocyte Induced Maturation Protein 1 antibody
- Beta interferon gene positive regulatory domain I binding factor antibody
- Beta-interferon gene positive regulatory domain I-binding factor antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab119401 被引用在 3 文献中.
- Zeng F et al. KPNA2 interaction with CBX8 contributes to the development and progression of bladder cancer by mediating the PRDM1/c-FOS pathway. J Transl Med 19:112 (2021). PubMed: 33731128
- Yang J et al. T-cell-derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2. FASEB J 33:12780-12799 (2019). PubMed: 31480861
- Chen JL et al. Suppression of SIK1 by miR-141 in human ovarian cancer cell lines and tissues. Int J Mol Med 37:1601-10 (2016). PubMed: 27081781