PR 619,DUB抑制剂(ab144641)
Key features and details
- Cell-permeable, non-selective and reversible DUB inhibitor
- CAS Number: 2645-32-1
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
PR 619,DUB抑制剂 -
描述
Cell-permeable,non-selective and reversible DUB抑制剂 -
生物学描述
Cell-permeable, non-selective and reversible DUB inhibitor (IC50 values are 5 to 20 μM). Induces polyubiquitinated protein accumulation in cells without directly affecting proteasome activity. Activates autophagy.
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纯度
> 99% -
CAS编号
2645-32-1 -
化学结构
性能
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化学名称
Thiocyanic acid 2,6-diamino-3,5-pyridinediyl ester -
分子量
223.27 -
分子式
C7H5N5S2 -
PubChem识别号
2817763 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=C(C(=NC(=C1SC#N)N)N)SC#N -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (9)
ab144641 被引用在 9 文献中.
- Karapurkar JK et al. CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis. J Exp Clin Cancer Res 42:121 (2023). PubMed: 37170124
- Tyagi A et al. CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells. Theranostics 12:5949-5970 (2022). PubMed: 35966591
- Cao WX et al. Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition. Cell Rep 31:107783 (2020). PubMed: 32579915
- Das S et al. Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer. Cell Death Differ N/A:N/A (2020). PubMed: 32415280
- Ohsugi T et al. Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/ß-catenin signaling in colorectal cancer cells. Oncogene 38:6051-6064 (2019). PubMed: 31292489
- Skelly MJ et al. Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1. Elife 8:N/A (2019). PubMed: 31589140
- Tsuchiya H et al. Ub-ProT reveals global length and composition of protein ubiquitylation in cells. Nat Commun 9:524 (2018). PubMed: 29410401
- Ashkenazi A et al. Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature 545:108-111 (2017). PubMed: 28445460
- Inano S et al. RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination. Mol Cell 66:622-634.e8 (2017). PubMed: 28575658