Anti-PPP6C抗体(ab115885)

概述

  • 产品名称Anti-PPP6C抗体
    参阅全部 PPP6C 一抗
  • 描述
    兔多克隆抗体to PPP6C
  • 经测试应用适用于: WB, IP, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide:

    AVPDSERVIPPRTTTPY

    conjugated to KLH, corresponding to amino acids 287-303 of PPP6C

  • 阳性对照
    • IHC-P: Human Testis tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.08% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab115885 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 35 kDa.
IP Use at an assay dependent concentration.
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Catalytic subunit of protein phospatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.
  • 组织特异性Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.
  • 序列相似性Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ92648 antibody
    • MGC12249 antibody
    • PP 6 antibody
    • PP6 antibody
    • PP6C antibody
    • PPP 6 antibody
    • PPP 6C antibody
    • PPP6 antibody
    • PPP6_HUMAN antibody
    • Ppp6c antibody
    • Protein phosphatase 6 catalytic subunit antibody
    • Serine/threonine protein phosphatase 6 antibody
    • Serine/threonine protein phosphatase catalytic subunit antibody
    • Serine/threonine-protein phosphatase 6 catalytic subunit antibody
    see all

Anti-PPP6C antibody 图像

  • Human Testis (formalin-fixed, paraffin-embedded) stained with ab115885 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-PPP6C antibody (ab115885)参考文献

ab115885 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your interest in Abcam's PPP6C antibodies. Regarding ab16474 and ab115885, I have aligned the immunogen sequence with the Drosophila sequence and have found only 76% identity between the two sequences.  We would not predict that they ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"