概述

  • 产品名称Anti-PPP2R2B抗体
    参阅全部 PPP2R2B 一抗
  • 描述
    小鼠单克隆抗体to PPP2R2B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: QNAAYFLLST NDKTVKLWKV SERDKRPEGY NLKDEEGRLR DPATITTLRV PVLRPMDLMV EATPRRVFAN AHTYHINSIS VNSDYETYMS ADDLRINLWN , corresponding to amino acids 101-200 of Human PPP2R2B

性能

应用

Our Abpromise guarantee covers the use of ab58152 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
    • 组织特异性Brain.
    • 疾病相关Defects in PPP2R2B are the cause of spinocerebellar ataxia type 12 (SCA12) [MIM:604326]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA).
    • 序列相似性Belongs to the phosphatase 2A regulatory subunit B family.
      Contains 7 WD repeats.
    • 结构域The N-terminal 26 residues of isoform 2 constitute a cryptic mitochondrial matrix import signal with critical basic and hydrophobic residues, that is necessary and sufficient for targeting the PP2A holoenzyme to the outer mitochondrial membrane (OMM) and does not affect holoenzyme formation or catalytic activity.
      The last WD repeat of isoform 2 constitutes a mitochondrial stop-transfer domain that confers resistance to the unfolding step process required for import and therefore prevents PPP2R2B matrix translocation and signal sequence cleavage.
    • 细胞定位Cytoplasm. Cytoplasm > cytoskeleton. Membrane and Cytoplasm. Mitochondrion. Mitochondrion outer membrane. Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 2ABB_HUMAN antibody
      • B55 beta antibody
      • Beta isoform of regulatory subunit B55 protein phosphatase 2 antibody
      • MGC24888 antibody
      • PP2A B55beta antibody
      • PP2A PR55B antibody
      • PP2A subunit B B beta isoform antibody
      • PP2A subunit B B55 beta isoform antibody
      • PP2A subunit B isoform B55 beta antibody
      • PP2A subunit B isoform B55-beta antibody
      • PP2A subunit B isoform beta antibody
      • PP2A subunit B isoform PR55 beta antibody
      • PP2A subunit B isoform PR55-beta antibody
      • PP2A subunit B isoform R2 beta antibody
      • PP2A subunit B isoform R2-beta antibody
      • PP2A subunit B PR55 beta isoform antibody
      • PP2A subunit B R2 beta isoform antibody
      • Ppp2r2b antibody
      • PR2AB beta antibody
      • PR2AB55 beta antibody
      • PR2APR55 beta antibody
      • PR52B antibody
      • PR55 beta antibody
      • Protein phosphatase 2 (formerly 2A) regulatory subunit B (PR 52) beta isoform antibody
      • Protein phosphatase 2 (formerly 2A) regulatory subunit B beta isoform antibody
      • Protein phosphatase 2 regulatory subunit B antibody
      • Protein phosphatase 2 regulatory subunit B beta isoform antibody
      • SCA 12 antibody
      • SCA12 antibody
      • Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform antibody
      • Serine/threonine protein phosphatase 2A neuronal isoform antibody
      • Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform antibody
      see all

    Anti-PPP2R2B antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab58152 PPP2R2B antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-PPP2R2B antibody (ab58152)参考文献

    ab58152 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab58152.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"