概述

  • 产品名称Anti-PPP1R3B抗体
    参阅全部 PPP1R3B 一抗
  • 描述
    兔多克隆抗体to PPP1R3B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Goat, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 40-89 (LSSKNEASGM VAPAVQEKKV KKRVSFADNQ GLALTMVKVF SEFDDPLDMP) of Human PPP1R3B (NP_078883).

  • 阳性对照
    • MCF7 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab116642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
  • 组织特异性Highly expressed in liver. Expressed moderately in skeletal muscle and myotubes (at protein level). Expressed predominantly in heart and skeletal muscle. Expressed moderately in liver. Expressed weakly in placenta, lung and kidney.
  • 序列相似性Contains 1 CBM21 (carbohydrate binding type-21) domain.
  • 结构域The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ14005 antibody
    • FLJ34675 antibody
    • GL antibody
    • Hepatic glycogen targeting protein phosphatase 1 regulatory subunit GL antibody
    • Hepatic glycogen targeting subunit G(L) antibody
    • Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL antibody
    • PP1 subunit R4 antibody
    • Ppp1r3b antibody
    • PPP1R4 antibody
    • PPR3B_HUMAN antibody
    • Protein phosphatase 1 regulatory (inhibitor) subunit 3B antibody
    • Protein phosphatase 1 regulatory subunit 3B antibody
    • Protein phosphatase 1 regulatory subunit 4 antibody
    • Protein phosphatase 1 subunit 4 antibody
    • Protein phosphatase 1 subunit GL antibody
    • PTG antibody
    • R4 antibody
    see all

Anti-PPP1R3B antibody 图像

  • Anti-PPP1R3B antibody (ab116642) at 1 µg/ml + MCF7 cell lysate at 10 µg

    Predicted band size : 33 kDa

Anti-PPP1R3B antibody (ab116642)参考文献

ab116642 has not yet been referenced specifically in any publications.

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