概述

  • 产品名称Anti-PPP1R10抗体
    参阅全部 PPP1R10 一抗
  • 描述
    兔多克隆抗体to PPP1R10
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 350-400 (

    DRPGTPVPPVEVPELMDTASLEPGALDAKPVESPGDPNQLTRKGRKRKSV T

    ) of human PPP1R10 (SwissProt Q96QC0).

  • 阳性对照
    • Human breast adenocarcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab84377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    Antigen exposure is recommended.
    Antigen exposure with citrate buffer will enhance staining.
    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性PPP1R10 (serine/threonine protein phosphatase 1 regulatory subunit 10), also known as PNUTS, is a targeting subunit of protein phosphatase 1 (PP1). Furthermore, PPP1R10 acts as an inhibitor of PPP1CA and PPP1CC phosphatase activities. Its inhibitory activity on PPP1CA is only observed when PPP1R10 is phosphorylated by Protein Kinase A (PKA). PPP1R10 contains a zinc finger motif and is predominantly localised within the nucleus. Recently, PPP1R10 has been shown to target PP1 to GABA(C) receptors, shuttling from the nucleus to the cell membrane in cells co-expressing this receptor. This highlights a role for this protein in the regulation of synaptic signal transduction. PPP1R10 has also been shown to regulate the activity of p53 in response to hypoxia.
    • 细胞定位Nucleus. Note: Found in discrete nucleoplasmic bodies and within nucleoli.
    • 数据库链接
    • 别名
      • CAT 53 antibody
      • CAT53 antibody
      • FB 19 antibody
      • FB19 antibody
      • FB19 protein antibody
      • HLA-C associated transcript 53 antibody
      • MHC class I region proline rich protein CAT53 antibody
      • p99 antibody
      • Phosphatase 1 nuclear targeting subunit antibody
      • Phosphatase nuclear targeting subunit antibody
      • PNUTS antibody
      • PP1 binding protein of 114 kDa antibody
      • PP1 nuclear targeting subunit antibody
      • PP1R10 antibody
      • protein FB19 antibody
      • Protein phosphatase 1 nuclear targeting subunit antibody
      • Protein phosphatase 1 regulatory (inhibitor) subunit 10 antibody
      • Protein phosphatase 1 regulatory subunit 10 antibody
      • R111 antibody
      • Serine/threonine protein phosphatase 1 regulatory subunit 10 antibody
      see all

    Anti-PPP1R10 antibody 图像

    • ab84377 at 1/250, staining human PPP1R10 in a section of human breast adenocarcinoma by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

    Anti-PPP1R10 antibody (ab84377)参考文献

    ab84377 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab84377.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"