概述

  • 产品名称Anti-PPP1R10抗体
    参阅全部 PPP1R10 一抗
  • 描述
    兔多克隆抗体to PPP1R10
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Chimpanzee, Non Human Primates, Rhesus monkey
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 150 - 250 of Human PPP1R10.

    (Peptide available as ab74587.)

  • 阳性对照
    • This antibody gave a positive signal in HeLa Nuclear Lysate.

性能

应用

Our Abpromise guarantee covers the use of ab66040 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 99 kDa).

靶标

  • 相关性PPP1R10 (serine/threonine protein phosphatase 1 regulatory subunit 10), also known as PNUTS, is a targeting subunit of protein phosphatase 1 (PP1). Furthermore, PPP1R10 acts as an inhibitor of PPP1CA and PPP1CC phosphatase activities. Its inhibitory activity on PPP1CA is only observed when PPP1R10 is phosphorylated by Protein Kinase A (PKA). PPP1R10 contains a zinc finger motif and is predominantly localised within the nucleus. Recently, PPP1R10 has been shown to target PP1 to GABA(C) receptors, shuttling from the nucleus to the cell membrane in cells co-expressing this receptor. This highlights a role for this protein in the regulation of synaptic signal transduction. PPP1R10 has also been shown to regulate the activity of p53 in response to hypoxia.
  • 细胞定位Nucleus. Note: Found in discrete nucleoplasmic bodies and within nucleoli.
  • 数据库链接
  • 别名
    • CAT 53 antibody
    • CAT53 antibody
    • FB 19 antibody
    • FB19 antibody
    • FB19 protein antibody
    • HLA-C associated transcript 53 antibody
    • MHC class I region proline rich protein CAT53 antibody
    • p99 antibody
    • Phosphatase 1 nuclear targeting subunit antibody
    • Phosphatase nuclear targeting subunit antibody
    • PNUTS antibody
    • PP1 binding protein of 114 kDa antibody
    • PP1 nuclear targeting subunit antibody
    • PP1R10 antibody
    • protein FB19 antibody
    • Protein phosphatase 1 nuclear targeting subunit antibody
    • Protein phosphatase 1 regulatory (inhibitor) subunit 10 antibody
    • Protein phosphatase 1 regulatory subunit 10 antibody
    • R111 antibody
    • Serine/threonine protein phosphatase 1 regulatory subunit 10 antibody
    see all

Anti-PPP1R10 antibody 图像

  • Anti-PPP1R10 antibody (ab66040) at 1 µg/ml + HeLa (Human epithelial carcinoma cell line) Nuclear Lysate at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Performed under reducing conditions.

    Predicted band size : 99 kDa
    Observed band size : 110 kDa (why is the actual band size different from the predicted?)


    Exposure time : 1 minute

Anti-PPP1R10 antibody (ab66040)参考文献

ab66040 has not yet been referenced specifically in any publications.

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