概述

  • 产品名称Anti-PPP1A抗体
    参阅全部 PPP1A 一抗
  • 描述
    兔多克隆抗体to PPP1A
  • 特异性This antibody detects endogenous levels of total PPP1A protein.
  • 经测试应用适用于: IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    A synthesized non-phosphopeptide derived from human PPP1A around the phosphorylation site of threonine 320

  • 阳性对照
    • Human breast carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab62625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100.
ELISA 1/5000.

靶标

  • 功能Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
  • 序列相似性Belongs to the PPP phosphatase family. PP-1 subfamily.
  • 细胞定位Cytoplasm. Nucleus. Nucleus > nucleoplasm. Nucleus > nucleolus. Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit antibody
    • Catalytic subunit antibody
    • EC 3.1.3.16 antibody
    • MGC15877 antibody
    • MGC1674 antibody
    • PP 1A antibody
    • PP-1A antibody
    • PP1A antibody
    • PP1A_HUMAN antibody
    • PP1alpha antibody
    • PP2C ALPHA antibody
    • PP2CA antibody
    • Ppp1ca antibody
    • Protein Phosphatase 2C Alpha Isoform antibody
    • Serine threonine protein phosphatase PP1 alpha catalytic subunit antibody
    • Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1 antibody
    • Serine/threonine-protein phosphatase PP1-alpha catalytic subunit antibody
    see all

Anti-PPP1A antibody 图像

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ab62625 at a 1:50 dilution.

    Left image untreated.

    Right image treated with peptide.

Anti-PPP1A antibody (ab62625)参考文献

ab62625 has not yet been referenced specifically in any publications.

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