概述

  • 产品名称Anti-PPOX抗体
    参阅全部 PPOX 一抗
  • 描述
    兔多克隆抗体to PPOX
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (SERLGGWIRS VRGPNGAIFE LGPRGIRPAG ALGARTLLLV SELGLDSEVL) of Human PPOX (NP_000300).

  • 阳性对照
    • HT1080 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab94531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 51 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
  • 组织特异性Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 通路Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
  • 疾病相关Defects in PPOX are the cause of variegate porphyria (VP) [MIM:176200]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. PV is the most common form of porphyria in South Africa. It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances. High fecal levels of protoporphyrin and coproporphyrin, increased urine uroporphyrins and iron overload are typical markers of the disease.
  • 序列相似性Belongs to the protoporphyrinogen oxidase family.
  • 细胞定位Mitochondrion inner membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC8485 antibody
    • PPO antibody
    • PPOX antibody
    • PPOX_HUMAN antibody
    • Protoporphyrinogen oxidase antibody
    • V290M antibody
    • Variegate porphyria antibody
    • VP antibody
    see all

Anti-PPOX antibody 图像

  • Anti-PPOX antibody (ab94531) at 1 µg/ml (in 5% skim milk / PBS buffer) + HT1080 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 51 kDa

Anti-PPOX antibody (ab94531)参考文献

ab94531 has not yet been referenced specifically in any publications.

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