概述

  • 产品名称Anti-PPOX抗体
    参阅全部 PPOX 一抗
  • 描述
    小鼠单克隆抗体to PPOX
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: EASGCVLSQE LFQQRAQEAA ATQLGLKEMP SHCLVHLHKN CIPQYTLGHW QKLESARQFL TAHRLPLTLA GASYEGVAVN DCIESGRQAA VSVLGTEPNS , corresponding to amino acids 378-478 of Human PPOX

性能

应用

Our Abpromise guarantee covers the use of ab58147 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
    • 组织特异性Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    • 通路Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
    • 疾病相关Defects in PPOX are the cause of variegate porphyria (VP) [MIM:176200]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. PV is the most common form of porphyria in South Africa. It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances. High fecal levels of protoporphyrin and coproporphyrin, increased urine uroporphyrins and iron overload are typical markers of the disease.
    • 序列相似性Belongs to the protoporphyrinogen oxidase family.
    • 细胞定位Mitochondrion inner membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • MGC8485 antibody
      • PPO antibody
      • PPOX antibody
      • PPOX_HUMAN antibody
      • Protoporphyrinogen oxidase antibody
      • V290M antibody
      • Variegate porphyria antibody
      • VP antibody
      see all

    Anti-PPOX antibody 图像

    • PPOX antibody (ab58147) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human lung, adenosqumous cell carcinoma.
    • Western blot against tagged recombinant protein immunogen using ab58147 PPOX antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-PPOX antibody (ab58147)参考文献

    ab58147 has not yet been referenced specifically in any publications.

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