The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Detects a band of approximately 67 kDa (predicted molecular weight: 67 kDa).
功能Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.
序列相似性Belongs to the PP2C family. Contains 1 PP2C-like domain.
protein phosphatase 1D magnesium-dependent delta isoform antibody
Protein phosphatase 2C delta isoform antibody
Protein phosphatase 2C isoform delta antibody
Protein phosphatase magnesium dependent 1 delta antibody
Protein phosphatase magnesium-dependent 1 delta antibody
Protein phosphatase Mg2+/Mn2+ dependent 1D antibody
Protein phosphatase Wip1 antibody
Wild type p53 induced phosphatase 1 antibody
WIP 1 antibody
Anti-PPM1D antibody 图像
Western blot - PPM1D antibody (ab37495)
Anti-PPM1D antibody (ab37495) + 293 cell lysate
Predicted band size : 67 kDa Observed band size : 67 kDa
Anti-PPM1D antibody (ab37495)参考文献
This product has been referenced in:
Ali AY et al. The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation. Oncogene : (2011).
Read more (PubMed: 21927021) »