The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500.
功能PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.
序列相似性Contains 1 PPIase cyclophilin-type domain.
结构域The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II.
翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
细胞定位Nucleus matrix. Nucleus speckle. Colocalizes with RNA splicing factors at nuclear speckles.