Anti-PPAP2A抗体(ab198280)
Key features and details
- Rabbit polyclonal to PPAP2A
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-PPAP2A抗体
参阅全部 PPAP2A 一抗 -
描述
兔多克隆抗体to PPAP2A -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Human PPAP2A (internal sequence). (NP_003702).
Database link: O14494 -
阳性对照
- Human liver cancer tissue lysate; Human breast cancer tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab198280于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/25 - 1/100.
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WB |
1/500 - 1/2000. Predicted molecular weight: 32 kDa.
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说明 |
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IHC-P
1/25 - 1/100. |
WB
1/500 - 1/2000. Predicted molecular weight: 32 kDa. |
靶标
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功能
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. -
组织特异性
Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas. -
序列相似性
Belongs to the PA-phosphatase related phosphoesterase family. -
翻译后修饰
N-glycosylated. Contains high-mannose oligosaccharides. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 8611 Human
- Entrez Gene: 19012 Mouse
- Entrez Gene: 64369 Rat
- Omim: 607124 Human
- SwissProt: O14494 Human
- SwissProt: Q61469 Mouse
- SwissProt: O08564 Rat
- Unigene: 696231 Human
see all -
别名
- Lipid phosphate phosphohydrolase 1 antibody
- Lipid phosphate phosphohydrolase 1a antibody
- LLP1a antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab198280 被引用在 2 文献中.
- Huang Q et al. Stimulated phospholipid synthesis is key for hepatitis B virus replications. Sci Rep 9:12989 (2019). PubMed: 31506451
- Hu Q et al. Lipid profile of platelets and platelet-derived microparticles in ovarian cancer. BBA Clin 6:76-81 (2016). WB ; Human . PubMed: 27453821