概述

  • 产品名称
    Anti-PP2A beta抗体
    参阅全部 PP2A beta 一抗
  • 描述
    兔多克隆抗体to PP2A beta
  • 特异性
    ab32673 recognises PP2A beta. Does not crossreact with PP1 or other protein phosphatases.
  • 经测试应用
    适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Rat, Rabbit, Human
    预测可用于: Chicken, Cow, Dog, Xenopus laevis, Caenorhabditis elegans, Drosophila melanogaster, Zebrafish, Cynomolgus monkey, Dictyostelium discoideum
  • 免疫原

    Synthetic peptide corresponding to Human PP2A beta aa 296-309 (C terminal) conjugated to keyhole limpet haemocyanin.
    Sequence:

    GEPHVTRRTPDYFL

  • 阳性对照
    • Rabbit brain membrane cytosol and human A431 RIPA cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab32673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 35 kDa.
IP Use a concentration of 4 - 5 µg/ml.

靶标

  • 功能
    PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
  • 序列相似性
    Belongs to the PPP phosphatase family. PP-1 subfamily.
  • 翻译后修饰
    Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. Demethylated by PME1 (in vitro).
    Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • 细胞定位
    Cytoplasm. Nucleus. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • PP2A beta antibody
    • PP2A-beta antibody
    • PP2AB_HUMAN antibody
    • PP2Abeta antibody
    • PP2CB antibody
    • Ppp2cb antibody
    • Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform antibody
    • Protein phosphatase 2 catalytic subunit beta isozyme antibody
    • Protein phosphatase 2, catalytic subunit, beta isoform antibody
    • Protein phosphatase 2A catalytic subunit beta isoform antibody
    • Protein phosphatase type 2A catalytic subunit antibody
    • Serine/threonine protein phosphatase 2A catalytic subunit beta antibody
    • Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform antibody
    see all

文献

ab32673 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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