概述

  • 产品名称Anti-PP1C gamma抗体
    参阅全部 PP1C gamma 一抗
  • 描述
    兔多克隆抗体to PP1C gamma
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Cow, Dog, Pig, Xenopus laevis, Rhesus monkey, Xenopus tropicalis , Platypus (Ornithorhynchus anatinus)
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 280-323 (GAMMSVDETL MCSFQILKPA EKKKPNATRP VTPPRGMITK QAKK) of Human PP1C gamma (NP_002701.1).

  • 阳性对照
    • Human breast carcinoma, ovarian carcinoma, prostate carcinoma

性能

应用

Our Abpromise guarantee covers the use of ab93864 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with tris EDTA pH 9.0 buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
    • 序列相似性Belongs to the PPP phosphatase family. PP-1 subfamily.
    • 细胞定位Cytoplasm. Nucleus. Nucleus > nucleolus. Nucleus > nucleoplasm. Nucleus speckle. Chromosome > centromere > kinetochore. Cleavage furrow. Midbody. Colocalizes with SPZ1 in the nucleus (By similarity). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase.
    • Information by UniProt
    • 数据库链接
    • 别名
      • PP 1G antibody
      • PP-1G antibody
      • PP1C antibody
      • PP1G antibody
      • PP1G_HUMAN antibody
      • PP1gamma antibody
      • PPP 1G antibody
      • PPP1CC antibody
      • PPP1G antibody
      • Protein phosphatase 1, catalytic subunit, gamma isozyme antibody
      • Protein phosphatase 1C catalytic subunit antibody
      • Serine/threonine phosphatase 1 gamma antibody
      • Serine/threonine protein phosphatase PP1 gamma catalytic subunit antibody
      • Serine/threonine-protein phosphatase PP1-gamma catalytic subunit antibody
      see all

    Anti-PP1C gamma antibody 图像

    • ab93864, at a 1/250 dilution, staining PP1C gamma in formalin fixed, paraffin embedded Human brest carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

    Anti-PP1C gamma antibody (ab93864)参考文献

    ab93864 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab93864.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"