概述

  • 产品名称
  • 描述
    兔多克隆抗体to POT1
  • 特异性
    ab67298 recognizes human POT1 variant 3.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Horse, Dog, Chimpanzee, Cynomolgus monkey, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide:

    MSLVPATNYIYTPLNQ

    conjugated to KLH, corresponding to N terminal amino acids 1-16 of Human POT1

  • 阳性对照
    • A lysate of C2 or HeLa Nuclear extract.

性能

应用

Our Abpromise guarantee covers the use of ab67298 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明
    WB: 1/1000 - 1/2000. Detects a band of approximately 55-58 kDa (predicted molecular weight for variant 3: ~60 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.
    • 组织特异性
      Ubiquitous.
    • 序列相似性
      Belongs to the telombin family.
    • 细胞定位
      Nucleus. Chromosome > telomere. Colocalizes with telomeric DNA.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DKFZP586D211 antibody
      • hPot 1 antibody
      • hPot1 antibody
      • POT 1 antibody
      • POT1 antibody
      • POT1 like telomere end-binding protein antibody
      • POT1 protection of telomeres 1 homolog antibody
      • POT1-like telomere end-binding protein antibody
      • POTE1_HUMAN antibody
      • Protection of telomeres 1 antibody
      • Protection of telomeres 1 homolog (S. pombe) antibody
      • Protection of telomeres protein 1 antibody
      see all

    实验方案

    文献

    ab67298 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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