RabMAb

Anti-PON1抗体[EPR2892] (ab92466)

概述

  • 产品名称Anti-PON1抗体[EPR2892]
    参阅全部 PON1 一抗
  • 描述
    兔单克隆抗体[EPR2892] to PON1
  • 经测试应用适用于: WB, IP, IHC-Pmore details
    不适用于: ICC
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to residues near the N terminus of Human PON1.

  • 阳性对照
    • WB: plasma cells and ovary carcinoma lysate; IHC-P: liver tissue.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

相关产品

应用

Our Abpromise guarantee covers the use of ab92466 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IP
IHC-P
  • 应用说明IHC-P: 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. The use of an HRP/AP polymerized secondary antibody is recommended.
    IP: 1/10 - 1/100.
    WB: 1/1000 - 1/10000. Predicted molecular weight: 40 kDa.

    Is unsuitable for ICC.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
    • 组织特异性Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
    • 疾病相关Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5) [MIM:612633]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients.
    • 序列相似性Belongs to the paraoxonase family.
    • 翻译后修饰Glycosylated.
      The signal sequence is not cleaved.
      Present in two forms, form B contains a disulfide bond, form A does not.
    • 细胞定位Secreted > extracellular space.
    • Information by UniProt
    • 数据库链接
    • 别名
      • A esterase 1 antibody
      • A-esterase 1 antibody
      • Aromatic esterase 1 antibody
      • Arylesterase 1 antibody
      • Arylesterase B type antibody
      • ESA antibody
      • Esterase A antibody
      • K 45 antibody
      • K-45 antibody
      • MVCD5 antibody
      • Paraoxonase 1 antibody
      • Paraoxonase antibody
      • Paraoxonase B type antibody
      • Paraoxonase, plasma antibody
      • Paraoxonase1 antibody
      • PON 1 antibody
      • PON antibody
      • PON1 antibody
      • PON1_HUMAN antibody
      • Serum aryldiakylphosphatase antibody
      • Serum aryldialkylphosphatase 1 antibody
      • Serum paraoxonase/arylesterase 1 antibody
      see all

    Anti-PON1 antibody [EPR2892] 图像

    • All lanes : Anti-PON1 antibody [EPR2892] (ab92466) at 1/1000 dilution

      Lane 1 : Human plasma cell lysate
      Lane 2 : ovarian cancer lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit IgG at 1/2000 dilution

      Predicted band size : 40 kDa
    • ab92466, at 1/100 dilution, staining PON1 in formalin-fixed, paraffin-embedded Human liver tissue.
    • ab92466 showing negative staining in Skeletal muscle tissue.

    • ab92466 showing negative staining in Normal colon tissue.

    • ab92466 showing negative staining in Normal breast tissue.

    • ab92466 showing negative staining in Normal brain tissue.

    Anti-PON1 antibody [EPR2892] (ab92466)参考文献

    ab92466 has not yet been referenced specifically in any publications.

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"