Anti-Polyoma virus,Medium T antigen抗体[PyMT] (ab15085)
Key features and details
- Rat monoclonal [PyMT] to Polyoma virus, Medium T antigen
- Suitable for: IP, ICC/IF, WB, ELISA
- Isotype: IgG2b
概述
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产品名称
Anti-Polyoma virus,Medium T antigen抗体[PyMT] -
描述
大鼠单克隆抗体[PyMT] to Polyoma virus,Medium T antigen -
宿主
Rat -
经测试应用
适用于: IP, ICC/IF, WB, ELISAmore details -
种属反应性
与反应: Polyomavirus -
免疫原
Synthetic peptide (N terminal).
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常规说明
Binds medium T antigen only, allows isolation of viral T antigens.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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Primary antibody说明
Binds medium T antigen only, allows isolation of viral T antigens. -
克隆
单克隆 -
克隆编号
PyMT -
骨髓瘤
NS1 -
同种型
IgG2b -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab15085于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IP |
Use at an assay dependent concentration.
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ICC/IF |
Use at an assay dependent concentration.
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WB | (1) |
Use at an assay dependent concentration.
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ELISA |
Use at an assay dependent concentration.
|
说明 |
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IP
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
ELISA
Use at an assay dependent concentration. |
靶标
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相关性
Middle T antigen (MT) is a 421-amino-acid protein associated with membranes and underlying cytoskeletal elements, and is associated with a tyrosine-specific protein kinase activity. It is the principal oncoprotein of polyomavirus that is necessary and often sufficient for transformation in vitro. MT delivered as a transgene or a retrovirus can induce tumors in a wide variety of tissues. Polyomavirus (PyV) is a small, double-stranded, closed-circular-DNA virus with an approximately 5-kb genome divided into two roughly equal regions. The late transcripts produce the viral capsid proteins, whereas the early region encodes three so-called tumor (T) antigens that are important for both productive infection and transformation. -
细胞定位
Cytoplasmic location in cells infected with virus. -
别名
- Middle T antigen antibody
- MT AG antibody
- MT antibody
- Polyoma virus middle t antigen antibody
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (19)
ab15085 被引用在 19 文献中.
- Sun L et al. Activating a collaborative innate-adaptive immune response to control metastasis. Cancer Cell 39:1361-1374.e9 (2021). PubMed: 34478639
- Li Y et al. Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell 54:593-607.e5 (2020). PubMed: 32668208
- Wrenn ED et al. Regulation of Collective Metastasis by Nanolumenal Signaling. Cell 183:395-410.e19 (2020). PubMed: 33007268
- DeVette CI et al. A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancer. Oncoimmunology 9:1685300 (2020). PubMed: 32002300
- Fein MR et al. Cancer cell CCR2 orchestrates suppression of the adaptive immune response. J Exp Med 217:N/A (2020). PubMed: 32667673