Anti-Polycystin 2抗体(ab55947)


  • 产品名称Anti-Polycystin 2抗体
    参阅全部 Polycystin 2 一抗
  • 描述
    兔多克隆抗体to Polycystin 2
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Recombinant fragment
    预测可用于: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to C-terminal residues of mouse Polycystin 2.



Our Abpromise guarantee covers the use of ab55947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 110 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.


  • 功能Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
  • 组织特异性Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.
  • 疾病相关Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:613095]. ADPKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy.
  • 序列相似性Belongs to the polycystin family.
    Contains 1 EF-hand domain.
  • 结构域The C-terminal coiled-coil domain binds calcium and undergoes a calcium-induced conformation change. It is implicated in oligomerization and the interaction with PKD1.
  • 细胞定位Membrane. Endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APKD2 antibody
    • Autosomal dominant polycystic kidney disease type II antibody
    • Autosomal dominant polycystic kidney disease type II protein antibody
    • MGC138466 antibody
    • MGC138468 antibody
    • PC 2 antibody
    • PC2 antibody
    • PKD 2 antibody
    • PKD2 antibody
    • PKD2_HUMAN antibody
    • PKD4 antibody
    • Polycystic kidney disease 2 (autosomal dominant) antibody
    • Polycystic kidney disease 2 antibody
    • Polycystic kidney disease 2 protein antibody
    • Polycystin 2 antibody
    • Polycystin 2 transient receptor potential cation channel antibody
    • Polycystin-2 antibody
    • Polycystin2 antibody
    • Polycystwin antibody
    • R48321 antibody
    • Transient receptor potential cation channel subfamily P member 2 antibody
    • TRPP2 antibody
    see all

Anti-Polycystin 2 antibody 图像

  • Anti-Polycystin 2 antibody (ab55947) at 1 µg/ml + HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate at 10 µg

    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Predicted band size : 110 kDa
    Observed band size : 100 kDa (why is the actual band size different from the predicted?)

Anti-Polycystin 2 antibody (ab55947)参考文献

ab55947 has not yet been referenced specifically in any publications.

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