概述

  • 产品名称Anti-POLR3F抗体
    参阅全部 POLR3F 一抗
  • 描述
    兔多克隆抗体to POLR3F
  • 经测试应用适用于: WB, ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic 21 amino acid peptide from near the amino terminus of human POLR3F (CAC11110).

  • 阳性对照
    • Human brain tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab76951 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 36 kDa.
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 2.5 µg/ml.

靶标

  • 功能DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
  • 序列相似性Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DNA directed RNA polymerase III 39 kDa polypeptide antibody
    • DNA directed RNA polymerase III 39 kDa polypeptide F antibody
    • DNA directed RNA polymerase III subunit F antibody
    • DNA directed RNA polymerase III subunit RPC6 antibody
    • DNA directed RNA polymerases III 39 kDa polypeptide antibody
    • DNA-directed RNA polymerase III subunit F antibody
    • DNA-directed RNA polymerase III subunit RPC6 antibody
    • MGC13517 antibody
    • Polr3f antibody
    • Polymerase (RNA) III (DNA directed) polypeptide F antibody
    • RNA polymerase III 39 kDa subunit antibody
    • RNA polymerase III C39 subunit antibody
    • RNA polymerase III subunit C6 antibody
    • RPC 39 antibody
    • RPC 6 antibody
    • RPC39 antibody
    • RPC6 antibody
    • RPC6_HUMAN antibody
    see all

Anti-POLR3F antibody 图像

  • Immunofluorescence of POLR3F in Human brain tissue with ab76951 at 20 ug/mL.

  • Lane 1 : Anti-POLR3F antibody (ab76951) at 0.5 µg/ml
    Lane 2 : Anti-POLR3F antibody (ab76951) at 1 µg/ml

    Lane 1 : Human brain tissue lysate
    Lane 2 : Human brain tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 36 kDa
    Observed band size : 35 kDa (why is the actual band size different from the predicted?)
  • ab76951 at 2.5µg/ml staining SOLR3F in human brain tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded tissue sections).

Anti-POLR3F antibody (ab76951)参考文献

ab76951 has not yet been referenced specifically in any publications.

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